FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982276721> ?p ?o ?g. }

• W1982276721 endingPage "5434" @default.
• W1982276721 startingPage "5421" @default.
• W1982276721 abstract "Abstract Emerging evidence suggests that cytotoxic therapy may actually promote drug resistance and metastasis while inhibiting the growth of primary tumors. Work in preclinical models of breast cancer has shown that acquired chemoresistance to the widely used drug paclitaxel can be mediated by activation of the Toll-like receptor TLR4 in cancer cells. In this study, we determined the prometastatic effects of tumor-expressed TLR4 and paclitaxel therapy and investigated the mechanisms mediating these effects. While paclitaxel treatment was largely efficacious in inhibiting TLR4-negative tumors, it significantly increased the incidence and burden of pulmonary and lymphatic metastasis by TLR4-positive tumors. TLR4 activation by paclitaxel strongly increased the expression of inflammatory mediators, not only locally in the primary tumor microenvironment but also systemically in the blood, lymph nodes, spleen, bone marrow, and lungs. These proinflammatory changes promoted the outgrowth of Ly6C+ and Ly6G+ myeloid progenitor cells and their mobilization to tumors, where they increased blood vessel formation but not invasion of these vessels. In contrast, paclitaxel-mediated activation of TLR4-positive tumors induced de novo generation of deep intratumoral lymphatic vessels that were highly permissive to invasion by malignant cells. These results suggest that paclitaxel therapy of patients with TLR4-expressing tumors may activate systemic inflammatory circuits that promote angiogenesis, lymphangiogenesis, and metastasis, both at local sites and premetastatic niches where invasion occurs in distal organs. Taken together, our findings suggest that efforts to target TLR4 on tumor cells may simultaneously quell local and systemic inflammatory pathways that promote malignant progression, with implications for how to prevent tumor recurrence and the establishment of metastatic lesions, either during chemotherapy or after it is completed. Cancer Res; 74(19); 5421–34. ©2014 AACR." @default.
• W1982276721 created "2016-06-24" @default.
• W1982276721 creator A5012599222 @default.
• W1982276721 creator A5046254697 @default.
• W1982276721 creator A5052903219 @default.
• W1982276721 creator A5053573169 @default.
• W1982276721 creator A5066901504 @default.
• W1982276721 creator A5072496703 @default.
• W1982276721 creator A5080220346 @default.
• W1982276721 date "2014-09-30" @default.
• W1982276721 modified "2023-10-16" @default.
• W1982276721 title "Paclitaxel Therapy Promotes Breast Cancer Metastasis in a TLR4-Dependent Manner" @default.
• W1982276721 cites W1271389891 @default.
• W1982276721 cites W1520571564 @default.
• W1982276721 cites W1602880342 @default.
• W1982276721 cites W1915121024 @default.
• W1982276721 cites W1964317462 @default.
• W1982276721 cites W1964613165 @default.
• W1982276721 cites W1972041876 @default.
• W1982276721 cites W1980673092 @default.
• W1982276721 cites W1982441587 @default.
• W1982276721 cites W1992774812 @default.
• W1982276721 cites W2008358336 @default.
• W1982276721 cites W2011509273 @default.
• W1982276721 cites W2021176845 @default.
• W1982276721 cites W2021891258 @default.
• W1982276721 cites W2034277378 @default.
• W1982276721 cites W2034409870 @default.
• W1982276721 cites W2036097821 @default.
• W1982276721 cites W2038918212 @default.
• W1982276721 cites W2046118760 @default.
• W1982276721 cites W2048214675 @default.
• W1982276721 cites W2050864169 @default.
• W1982276721 cites W2053479613 @default.
• W1982276721 cites W2054683516 @default.
• W1982276721 cites W2062946715 @default.
• W1982276721 cites W2064315259 @default.
• W1982276721 cites W2073921028 @default.
• W1982276721 cites W2090640877 @default.
• W1982276721 cites W2094704890 @default.
• W1982276721 cites W2100351768 @default.
• W1982276721 cites W2101153911 @default.
• W1982276721 cites W2113192348 @default.
• W1982276721 cites W2117204942 @default.
• W1982276721 cites W2127515297 @default.
• W1982276721 cites W2129222816 @default.
• W1982276721 cites W2129746660 @default.
• W1982276721 cites W2136274729 @default.
• W1982276721 cites W2143684851 @default.
• W1982276721 cites W2151127655 @default.
• W1982276721 cites W2153017356 @default.
• W1982276721 cites W2159803625 @default.
• W1982276721 cites W2161015285 @default.
• W1982276721 cites W2161091841 @default.
• W1982276721 cites W2163035374 @default.
• W1982276721 cites W2171467964 @default.
• W1982276721 cites W2967276830 @default.
• W1982276721 cites W4251295232 @default.
• W1982276721 doi "https://doi.org/10.1158/0008-5472.can-14-0067" @default.
• W1982276721 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4185415" @default.
• W1982276721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25274031" @default.
• W1982276721 hasPublicationYear "2014" @default.
• W1982276721 type Work @default.
• W1982276721 sameAs 1982276721 @default.
• W1982276721 citedByCount "185" @default.
• W1982276721 countsByYear W19822767212015 @default.
• W1982276721 countsByYear W19822767212016 @default.
• W1982276721 countsByYear W19822767212017 @default.
• W1982276721 countsByYear W19822767212018 @default.
• W1982276721 countsByYear W19822767212019 @default.
• W1982276721 countsByYear W19822767212020 @default.
• W1982276721 countsByYear W19822767212021 @default.
• W1982276721 countsByYear W19822767212022 @default.
• W1982276721 countsByYear W19822767212023 @default.
• W1982276721 crossrefType "journal-article" @default.
• W1982276721 hasAuthorship W1982276721A5012599222 @default.
• W1982276721 hasAuthorship W1982276721A5046254697 @default.
• W1982276721 hasAuthorship W1982276721A5052903219 @default.
• W1982276721 hasAuthorship W1982276721A5053573169 @default.
• W1982276721 hasAuthorship W1982276721A5066901504 @default.
• W1982276721 hasAuthorship W1982276721A5072496703 @default.
• W1982276721 hasAuthorship W1982276721A5080220346 @default.
• W1982276721 hasBestOaLocation W19822767211 @default.
• W1982276721 hasConcept C121608353 @default.
• W1982276721 hasConcept C126322002 @default.
• W1982276721 hasConcept C203014093 @default.
• W1982276721 hasConcept C2776070231 @default.
• W1982276721 hasConcept C2776107976 @default.
• W1982276721 hasConcept C2776636583 @default.
• W1982276721 hasConcept C2776914184 @default.
• W1982276721 hasConcept C2777292972 @default.
• W1982276721 hasConcept C2779013556 @default.
• W1982276721 hasConcept C2779282312 @default.
• W1982276721 hasConcept C2780394083 @default.
• W1982276721 hasConcept C502942594 @default.
• W1982276721 hasConcept C71924100 @default.
• W1982276721 hasConceptScore W1982276721C121608353 @default.
• W1982276721 hasConceptScore W1982276721C126322002 @default.

• next