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• W1982277188 abstract "Reliable optical detection of single action potentials in mammalian neurons has been one of the longest-standing challenges in neuroscience. Here we achieved this goal by using the endogenous fluorescence of a microbial rhodopsin protein, Archaerhodopsin 3 (Arch) from Halorubrum sodomense, expressed in cultured rat hippocampal neurons. This genetically encoded voltage indicator exhibited an approximately tenfold improvement in sensitivity and speed over existing protein-based voltage indicators, with a roughly linear twofold increase in brightness between -150 mV and +150 mV and a sub-millisecond response time. Arch detected single electrically triggered action potentials with an optical signal-to-noise ratio >10. Arch(D95N) lacked endogenous proton pumping and had 50% greater sensitivity than wild type but had a slower response (41 ms). Nonetheless, Arch(D95N) also resolved individual action potentials. Microbial rhodopsin-based voltage indicators promise to enable optical interrogation of complex neural circuits and electrophysiology in systems for which electrode-based techniques are challenging." @default.
• W1982277188 created "2016-06-24" @default.
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• W1982277188 creator A5088434377 @default.
• W1982277188 date "2011-11-27" @default.
• W1982277188 modified "2023-10-18" @default.
• W1982277188 title "Optical recording of action potentials in mammalian neurons using a microbial rhodopsin" @default.
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• W1982277188 doi "https://doi.org/10.1038/nmeth.1782" @default.
• W1982277188 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3248630" @default.
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