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- W1982285502 abstract "To investigate the role of pre-core and basal core promoter (BCP) mutations before and after hepatitis B e antigen (HBeAg) seroconversion.The proportion of pre-core (G1896A) and basal core promoter (A1762T and G1764A) mutant viruses and serum levels of hepatitis B virus (HBV) DNA, hepatitis B surface antigen (HBsAg), and HB core-related antigen were analyzed in chronic hepatitis B patients before and after HBeAg seroconversion (n = 25), in those who were persistently HBeAg positive (n = 18), and in those who were persistently anti-HBe positive (n = 43). All patients were infected with HBV genotype C and were followed for a median of 9 years.Although the pre-core mutant became predominant (24% to 65%, P = 0.022) in the HBeAg seroconversion group during follow-up, the proportion of the basal core promoter mutation did not change. Median HBV viral markers were significantly higher in patients without the mutations in an HBeAg positive status (HBV DNA: P = 0.003; HBsAg: P < 0.001; HB core-related antigen: P = 0.001). In contrast, HBV DNA (P = 0.012) and HBsAg (P = 0.041) levels were significantly higher in patients with the pre-core mutation in an anti-HBe positive status.There is an opposite association of the pre-core mutation with viral load before and after HBeAg seroconversion in patients with HBV infection." @default.
- W1982285502 created "2016-06-24" @default.
- W1982285502 creator A5076248504 @default.
- W1982285502 date "2015-01-01" @default.
- W1982285502 modified "2023-10-03" @default.
- W1982285502 title "Mutations of pre-core and basal core promoter before and after hepatitis B e antigen seroconversion" @default.
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- W1982285502 doi "https://doi.org/10.3748/wjg.v21.i2.541" @default.
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