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• W1982292983 abstract "Neurons have significant potential for the homeostatic regulation of a broad range of functional features, from gene expression to synaptic excitability. In this article, we show that dendritic morphology may also be under intrinsic homeostatic control. We present the results from a statistical analysis of a large collection of digitally reconstructed neurons, demonstrating that fluctuations in dendritic size in one given portion of a neuron are systematically counterbalanced by the remaining dendrites in the same cell. As a result, the total dendritic measure (e.g., number of branches, length, and surface area) of each neuron in a given morphological class is, on average, significantly less random than would be expected if trees (and their parts) were regulated independently during development. This observation is general across scales that range from gross basal/apical subdivisions to individual branches and bifurcations, and its statistical significance is robust among various brain regions, cell types, and experimental conditions. Given the pivotal dendritic role in signal integration, synaptic plasticity, and network connectivity, these findings add a dimension to the functional characterization of neuronal homeostasis." @default.
• W1982292983 created "2016-06-24" @default.
• W1982292983 creator A5043347767 @default.
• W1982292983 creator A5087672831 @default.
• W1982292983 date "2006-01-17" @default.
• W1982292983 modified "2023-10-10" @default.
• W1982292983 title "Morphological homeostasis in cortical dendrites" @default.
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• W1982292983 doi "https://doi.org/10.1073/pnas.0510057103" @default.
• W1982292983 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1327728" @default.
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