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• W1982310088 abstract "A series of six new amidoalcohols was designed and synthesized on the base of the camphor scaffold. Natural amino acids were transformed into their α-hydroxy analogues with retention of configuration, and attached to isobornylamine. The compounds were evaluated for their in vitro activity against Mycobacterium tuberculosis H37Rv. Some of the new compounds show 25 times higher activity than the classical anti-TB drug ethambutol. The activity shifts from micromolar to nanomolar inhibitory concentrations depending on the α-hydroxy acid moiety. Two of the most potent compounds exert low level of cytotoxic activity. These camphane-based amido-alcohols present promising potential lead compounds for further elaboration of antimycobacterial agents." @default.
• W1982310088 created "2016-06-24" @default.
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• W1982310088 date "2014-01-01" @default.
• W1982310088 modified "2023-09-30" @default.
• W1982310088 title "Synthesis and antimycobacterial activity of novel camphane-based agents" @default.
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• W1982310088 doi "https://doi.org/10.1016/j.bmcl.2013.11.050" @default.
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