Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982311420> ?p ?o ?g. }
- W1982311420 endingPage "469" @default.
- W1982311420 startingPage "454" @default.
- W1982311420 abstract "CD137 ligand (CD137L) has emerged as a powerful regulator of myelopoiesis that links emergency situations, such as infections, to the generation of additional myeloid cells, and to their activation and maturation. CD137L is expressed on the cell surface of hematopoietic stem and progenitor cells (HSPC) and antigen presenting cells (APC) as a transmembrane protein. The signaling of CD137L into HSPC induces their proliferation and differentiation to monocytes and macrophages, and in monocytes CD137L signaling induces differentiation to potent dendritic cells (DC). CD137L signaling is initiated by CD137 which is expressed by T cells, once they become activated. Some of these activated, CD137-expressing T cells migrate from the site of infection to the bone marrow where they interact with HSPC to induce myelopoiesis, or they induce monocyte to DC differentiation locally at the site of infection. Therapeutically, induction of CD137L signaling can be utilized to reinitiate myeloid differentiation in acute myeloid leukemia cells, and to generate potent DC for immunotherapy." @default.
- W1982311420 created "2016-06-24" @default.
- W1982311420 creator A5002283637 @default.
- W1982311420 creator A5045088174 @default.
- W1982311420 creator A5047066063 @default.
- W1982311420 creator A5080640808 @default.
- W1982311420 creator A5080823195 @default.
- W1982311420 creator A5090901129 @default.
- W1982311420 date "2014-06-18" @default.
- W1982311420 modified "2023-10-18" @default.
- W1982311420 title "Regulation of Myelopoiesis by CD137L Signaling" @default.
- W1982311420 cites W124239641 @default.
- W1982311420 cites W1499068539 @default.
- W1982311420 cites W1530625210 @default.
- W1982311420 cites W1601642693 @default.
- W1982311420 cites W1661544713 @default.
- W1982311420 cites W1757893380 @default.
- W1982311420 cites W1854559712 @default.
- W1982311420 cites W1912951449 @default.
- W1982311420 cites W1940307444 @default.
- W1982311420 cites W1944811313 @default.
- W1982311420 cites W1951892834 @default.
- W1982311420 cites W1965815409 @default.
- W1982311420 cites W1971408242 @default.
- W1982311420 cites W1982548908 @default.
- W1982311420 cites W1985801522 @default.
- W1982311420 cites W1986957385 @default.
- W1982311420 cites W1987866336 @default.
- W1982311420 cites W1993292630 @default.
- W1982311420 cites W1995828329 @default.
- W1982311420 cites W1998940492 @default.
- W1982311420 cites W1999752605 @default.
- W1982311420 cites W2001172296 @default.
- W1982311420 cites W2004150448 @default.
- W1982311420 cites W2004159506 @default.
- W1982311420 cites W2005821352 @default.
- W1982311420 cites W2012376370 @default.
- W1982311420 cites W2021442712 @default.
- W1982311420 cites W2029867949 @default.
- W1982311420 cites W2030534681 @default.
- W1982311420 cites W2030726748 @default.
- W1982311420 cites W2031602416 @default.
- W1982311420 cites W2034869164 @default.
- W1982311420 cites W2037231270 @default.
- W1982311420 cites W2037425884 @default.
- W1982311420 cites W2038897844 @default.
- W1982311420 cites W2038920846 @default.
- W1982311420 cites W2047665149 @default.
- W1982311420 cites W2048214173 @default.
- W1982311420 cites W2054934312 @default.
- W1982311420 cites W2055837079 @default.
- W1982311420 cites W2061341693 @default.
- W1982311420 cites W2063547594 @default.
- W1982311420 cites W2066015053 @default.
- W1982311420 cites W2066615317 @default.
- W1982311420 cites W2067033131 @default.
- W1982311420 cites W2067846706 @default.
- W1982311420 cites W2071065868 @default.
- W1982311420 cites W2075225271 @default.
- W1982311420 cites W2077137777 @default.
- W1982311420 cites W2080808232 @default.
- W1982311420 cites W2086046858 @default.
- W1982311420 cites W2086969890 @default.
- W1982311420 cites W2087315557 @default.
- W1982311420 cites W2092317746 @default.
- W1982311420 cites W2092972513 @default.
- W1982311420 cites W2094480590 @default.
- W1982311420 cites W2094918348 @default.
- W1982311420 cites W2097460448 @default.
- W1982311420 cites W2100820895 @default.
- W1982311420 cites W2101959282 @default.
- W1982311420 cites W2106982156 @default.
- W1982311420 cites W2111551833 @default.
- W1982311420 cites W2112122292 @default.
- W1982311420 cites W2113288263 @default.
- W1982311420 cites W2115855421 @default.
- W1982311420 cites W2126168881 @default.
- W1982311420 cites W2126657952 @default.
- W1982311420 cites W2131125667 @default.
- W1982311420 cites W2133562017 @default.
- W1982311420 cites W2133782563 @default.
- W1982311420 cites W2153887456 @default.
- W1982311420 cites W2154857447 @default.
- W1982311420 cites W2156666186 @default.
- W1982311420 cites W2158216603 @default.
- W1982311420 cites W2160579417 @default.
- W1982311420 cites W2164125465 @default.
- W1982311420 cites W2167213128 @default.
- W1982311420 cites W2170352596 @default.
- W1982311420 cites W2315562687 @default.
- W1982311420 cites W2325487268 @default.
- W1982311420 cites W2413768866 @default.
- W1982311420 cites W2414969937 @default.
- W1982311420 cites W62199461 @default.
- W1982311420 doi "https://doi.org/10.3109/08830185.2014.921163" @default.
- W1982311420 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24941289" @default.
- W1982311420 hasPublicationYear "2014" @default.
- W1982311420 type Work @default.