Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982314773> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W1982314773 abstract "Various drugs have been studied in order to improve the bioavailability of L-DOPA. In the present study, the alpha-ketoacid of L-DOPA, 3,4-dihydroxyphenylpyruvic acid (DHPPA) and its fully acetylated derivative, triacetoxyphenylpyruvic acid (TAPPA), were investigated. These substances were shown to be equally strong DOPA decarboxylase inhibitors in vitro. The inhibitory activity was, however, only about 1/2000 of that of carbidopa and 1/10 of that of L-alpha-methyldopa. In vivo studies in the rat showed that when either DHPPA or TAPPA was given orally concomitantly with L-DOPA, only DHPPA, which is a transaminase inhibitor, enhanced the L-DOPA induced rise in the cerebral dopamine concentration. TAPPA had, however, an enhancing effect on the L-DOPA-induced rise in the serum L-DOPA concentration. The weak L-DOPA-sparing effect of TAPPA could be explained by its inhibitory effect on DOPA decarboxylase and the marked L-DOPA-sparing effect of DHPPA by its action on both transamination and decarboxylation." @default.
- W1982314773 created "2016-06-24" @default.
- W1982314773 creator A5058554392 @default.
- W1982314773 creator A5069107425 @default.
- W1982314773 creator A5076752390 @default.
- W1982314773 date "2009-03-13" @default.
- W1982314773 modified "2023-09-27" @default.
- W1982314773 title "Effects of 3,4-Dihydroxyphenylpyruvic Acid and its Triacetylated Derivative on DOPA Decarboxylase" @default.
- W1982314773 cites W1985370543 @default.
- W1982314773 cites W1986110792 @default.
- W1982314773 cites W1987228165 @default.
- W1982314773 cites W1994748584 @default.
- W1982314773 cites W2011381010 @default.
- W1982314773 cites W2070110481 @default.
- W1982314773 cites W2108874406 @default.
- W1982314773 cites W2410185205 @default.
- W1982314773 cites W2417460917 @default.
- W1982314773 doi "https://doi.org/10.1111/j.1600-0773.1982.tb01024.x" @default.
- W1982314773 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7136732" @default.
- W1982314773 hasPublicationYear "2009" @default.
- W1982314773 type Work @default.
- W1982314773 sameAs 1982314773 @default.
- W1982314773 citedByCount "3" @default.
- W1982314773 crossrefType "journal-article" @default.
- W1982314773 hasAuthorship W1982314773A5058554392 @default.
- W1982314773 hasAuthorship W1982314773A5069107425 @default.
- W1982314773 hasAuthorship W1982314773A5076752390 @default.
- W1982314773 hasConcept C126322002 @default.
- W1982314773 hasConcept C134018914 @default.
- W1982314773 hasConcept C150903083 @default.
- W1982314773 hasConcept C161790260 @default.
- W1982314773 hasConcept C181199279 @default.
- W1982314773 hasConcept C181389837 @default.
- W1982314773 hasConcept C185592680 @default.
- W1982314773 hasConcept C202751555 @default.
- W1982314773 hasConcept C207001950 @default.
- W1982314773 hasConcept C2776754145 @default.
- W1982314773 hasConcept C2779134260 @default.
- W1982314773 hasConcept C2779734285 @default.
- W1982314773 hasConcept C2780304432 @default.
- W1982314773 hasConcept C2780595602 @default.
- W1982314773 hasConcept C513476851 @default.
- W1982314773 hasConcept C55493867 @default.
- W1982314773 hasConcept C58824617 @default.
- W1982314773 hasConcept C68793091 @default.
- W1982314773 hasConcept C71924100 @default.
- W1982314773 hasConcept C86803240 @default.
- W1982314773 hasConcept C98274493 @default.
- W1982314773 hasConceptScore W1982314773C126322002 @default.
- W1982314773 hasConceptScore W1982314773C134018914 @default.
- W1982314773 hasConceptScore W1982314773C150903083 @default.
- W1982314773 hasConceptScore W1982314773C161790260 @default.
- W1982314773 hasConceptScore W1982314773C181199279 @default.
- W1982314773 hasConceptScore W1982314773C181389837 @default.
- W1982314773 hasConceptScore W1982314773C185592680 @default.
- W1982314773 hasConceptScore W1982314773C202751555 @default.
- W1982314773 hasConceptScore W1982314773C207001950 @default.
- W1982314773 hasConceptScore W1982314773C2776754145 @default.
- W1982314773 hasConceptScore W1982314773C2779134260 @default.
- W1982314773 hasConceptScore W1982314773C2779734285 @default.
- W1982314773 hasConceptScore W1982314773C2780304432 @default.
- W1982314773 hasConceptScore W1982314773C2780595602 @default.
- W1982314773 hasConceptScore W1982314773C513476851 @default.
- W1982314773 hasConceptScore W1982314773C55493867 @default.
- W1982314773 hasConceptScore W1982314773C58824617 @default.
- W1982314773 hasConceptScore W1982314773C68793091 @default.
- W1982314773 hasConceptScore W1982314773C71924100 @default.
- W1982314773 hasConceptScore W1982314773C86803240 @default.
- W1982314773 hasConceptScore W1982314773C98274493 @default.
- W1982314773 hasLocation W19823147731 @default.
- W1982314773 hasLocation W19823147732 @default.
- W1982314773 hasOpenAccess W1982314773 @default.
- W1982314773 hasPrimaryLocation W19823147731 @default.
- W1982314773 hasRelatedWork W1514149104 @default.
- W1982314773 hasRelatedWork W1974570852 @default.
- W1982314773 hasRelatedWork W1982314773 @default.
- W1982314773 hasRelatedWork W1982704513 @default.
- W1982314773 hasRelatedWork W1996702064 @default.
- W1982314773 hasRelatedWork W2004176790 @default.
- W1982314773 hasRelatedWork W2026704744 @default.
- W1982314773 hasRelatedWork W2054703685 @default.
- W1982314773 hasRelatedWork W2060114224 @default.
- W1982314773 hasRelatedWork W2060598809 @default.
- W1982314773 isParatext "false" @default.
- W1982314773 isRetracted "false" @default.
- W1982314773 magId "1982314773" @default.
- W1982314773 workType "article" @default.