FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982323220> ?p ?o ?g. }

• W1982323220 endingPage "e1003393" @default.
• W1982323220 startingPage "e1003393" @default.
• W1982323220 abstract "After decades of using urea as denaturant, the kinetic role of this molecule in the unfolding process is still undefined: does urea actively induce protein unfolding or passively stabilize the unfolded state? By analyzing a set of 30 proteins (representative of all native folds) through extensive molecular dynamics simulations in denaturant (using a range of force-fields), we derived robust rules for urea unfolding that are valid at the proteome level. Irrespective of the protein fold, presence or absence of disulphide bridges, and secondary structure composition, urea concentrates in the first solvation shell of quasi-native proteins, but with a density lower than that of the fully unfolded state. The presence of urea does not alter the spontaneous vibration pattern of proteins. In fact, it reduces the magnitude of such vibrations, leading to a counterintuitive slow down of the atomic-motions that opposes unfolding. Urea stickiness and slow diffusion is, however, crucial for unfolding. Long residence urea molecules placed around the hydrophobic core are crucial to stabilize partially open structures generated by thermal fluctuations. Our simulations indicate that although urea does not favor the formation of partially open microstates, it is not a mere spectator of unfolding that simply displaces to the right of the folded ←→ unfolded equilibrium. On the contrary, urea actively favors unfolding: it selects and stabilizes partially unfolded microstates, slowly driving the protein conformational ensemble far from the native one and also from the conformations sampled during thermal unfolding." @default.
• W1982323220 created "2016-06-24" @default.
• W1982323220 creator A5006399866 @default.
• W1982323220 creator A5019450935 @default.
• W1982323220 creator A5023487324 @default.
• W1982323220 creator A5040619925 @default.
• W1982323220 creator A5063704705 @default.
• W1982323220 creator A5088134705 @default.
• W1982323220 creator A5090485630 @default.
• W1982323220 date "2013-12-12" @default.
• W1982323220 modified "2023-10-17" @default.
• W1982323220 title "Exploring Early Stages of the Chemical Unfolding of Proteins at the Proteome Scale" @default.
• W1982323220 cites W157808733 @default.
• W1982323220 cites W1966041739 @default.
• W1982323220 cites W1966867774 @default.
• W1982323220 cites W1972758026 @default.
• W1982323220 cites W1976499671 @default.
• W1982323220 cites W1977482735 @default.
• W1982323220 cites W1985716931 @default.
• W1982323220 cites W1989939737 @default.
• W1982323220 cites W1990161102 @default.
• W1982323220 cites W1997723318 @default.
• W1982323220 cites W2011630467 @default.
• W1982323220 cites W2020093892 @default.
• W1982323220 cites W2027408247 @default.
• W1982323220 cites W2029667189 @default.
• W1982323220 cites W2031188707 @default.
• W1982323220 cites W2034112681 @default.
• W1982323220 cites W2035687084 @default.
• W1982323220 cites W2038758364 @default.
• W1982323220 cites W2041189078 @default.
• W1982323220 cites W2045828736 @default.
• W1982323220 cites W2045933761 @default.
• W1982323220 cites W2050956052 @default.
• W1982323220 cites W2053599146 @default.
• W1982323220 cites W2060757799 @default.
• W1982323220 cites W2062913022 @default.
• W1982323220 cites W2064546088 @default.
• W1982323220 cites W2067337097 @default.
• W1982323220 cites W2075460992 @default.
• W1982323220 cites W2079875740 @default.
• W1982323220 cites W2085277871 @default.
• W1982323220 cites W2088780328 @default.
• W1982323220 cites W2096778928 @default.
• W1982323220 cites W2103208396 @default.
• W1982323220 cites W2103275034 @default.
• W1982323220 cites W2103751982 @default.
• W1982323220 cites W2106043217 @default.
• W1982323220 cites W2125823338 @default.
• W1982323220 cites W2127524427 @default.
• W1982323220 cites W2127821584 @default.
• W1982323220 cites W2131288855 @default.
• W1982323220 cites W2148077714 @default.
• W1982323220 cites W2150981663 @default.
• W1982323220 cites W2333054591 @default.
• W1982323220 doi "https://doi.org/10.1371/journal.pcbi.1003393" @default.
• W1982323220 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3861036" @default.
• W1982323220 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24348236" @default.
• W1982323220 hasPublicationYear "2013" @default.
• W1982323220 type Work @default.
• W1982323220 sameAs 1982323220 @default.
• W1982323220 citedByCount "14" @default.
• W1982323220 countsByYear W19823232202014 @default.
• W1982323220 countsByYear W19823232202015 @default.
• W1982323220 countsByYear W19823232202017 @default.
• W1982323220 countsByYear W19823232202018 @default.
• W1982323220 countsByYear W19823232202019 @default.
• W1982323220 countsByYear W19823232202020 @default.
• W1982323220 countsByYear W19823232202022 @default.
• W1982323220 countsByYear W19823232202023 @default.
• W1982323220 crossrefType "journal-article" @default.
• W1982323220 hasAuthorship W1982323220A5006399866 @default.
• W1982323220 hasAuthorship W1982323220A5019450935 @default.
• W1982323220 hasAuthorship W1982323220A5023487324 @default.
• W1982323220 hasAuthorship W1982323220A5040619925 @default.
• W1982323220 hasAuthorship W1982323220A5063704705 @default.
• W1982323220 hasAuthorship W1982323220A5088134705 @default.
• W1982323220 hasAuthorship W1982323220A5090485630 @default.
• W1982323220 hasBestOaLocation W19823232201 @default.
• W1982323220 hasConcept C104397665 @default.
• W1982323220 hasConcept C12554922 @default.
• W1982323220 hasConcept C139447449 @default.
• W1982323220 hasConcept C147597530 @default.
• W1982323220 hasConcept C148093993 @default.
• W1982323220 hasConcept C158617107 @default.
• W1982323220 hasConcept C159467904 @default.
• W1982323220 hasConcept C175188612 @default.
• W1982323220 hasConcept C178790620 @default.
• W1982323220 hasConcept C185592680 @default.
• W1982323220 hasConcept C19472624 @default.
• W1982323220 hasConcept C204328495 @default.
• W1982323220 hasConcept C2780365088 @default.
• W1982323220 hasConcept C32909587 @default.
• W1982323220 hasConcept C55493867 @default.
• W1982323220 hasConcept C59593255 @default.
• W1982323220 hasConcept C8010536 @default.
• W1982323220 hasConcept C86803240 @default.
• W1982323220 hasConceptScore W1982323220C104397665 @default.

• next