FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982326629> ?p ?o ?g. }

• W1982326629 endingPage "82" @default.
• W1982326629 startingPage "77" @default.
• W1982326629 abstract "The UGT1 complex codes for a subfamily of homologous 1A7-like UDP-glucuronosyltransferases (UGTs), including UGT1A7 and UGT1A8. Little information is available regarding either the substrate specificities or regulation of the UGT1A7-like forms from rats. We compared the activities and tissue expression of UGT1A7 and UGT1A8, which exhibit 77% identity in their amino terminal sequence. UGT1A7 shows broad specificity, catalyzing the glucuronidation of 31 of 40 randomly selected substrates (100 muM) at rates >0.1 nmol/mg/min. UGT1A7 substrates included both planar and nonplanar compounds, mono- and polycyclic aromatics, and compounds with bulky side chain ring substitutions. UGT1A8 exhibited a narrower substrate specificity that completely overlapped with UGT1A7. UGT1A8 was most active toward the 1-OH, 4-OH, 5-OH, 6-OH, 7-OH, 10-OH, 11-OH, and 12-OH derivatives of benzo[a]pyrene. Other effective UGT1A8 substrates (>0.1 nmol/mg/min) included 9-OH-benzo[a]pyrene, 1-naphthol, 4-methylumbelliferone, 7-hydroxycoumarin, chrysin, quercetin, 4-nitrophenol, and estriol. In general, substrates preferred by UGT1A8 were polyaromatic planar structures with nonbulky substituents and a superimposable 1-naphtho ring structure. Studies of the tissue expression of the UGT1A7 and 1A8 mRNAs using RNase protection analysis suggested that each is expressed in liver and kidney of control rats. A major difference is the higher expression of UGT1A7 mRNA in intestine. These studies suggest complementary functions of the UGT1A7 and UGT1A8 forms in xenobiotic metabolism. Further studies are necessary to determine whether their relative contributions change as a function of development, hormonal status, or exposure to inducing agents." @default.
• W1982326629 created "2016-06-24" @default.
• W1982326629 creator A5001380867 @default.
• W1982326629 creator A5036496656 @default.
• W1982326629 creator A5049741600 @default.
• W1982326629 creator A5063054979 @default.
• W1982326629 creator A5074319401 @default.
• W1982326629 date "2004-10-22" @default.
• W1982326629 modified "2023-10-08" @default.
• W1982326629 title "ANALYSIS OF SUBSTRATE SPECIFICITIES AND TISSUE EXPRESSION OF RAT UDP-GLUCURONOSYLTRANSFERASES UGT1A7 AND UGT1A8" @default.
• W1982326629 cites W1572023751 @default.
• W1982326629 cites W1970221032 @default.
• W1982326629 cites W1973780954 @default.
• W1982326629 cites W1975983777 @default.
• W1982326629 cites W2002673669 @default.
• W1982326629 cites W2011780463 @default.
• W1982326629 cites W2011837071 @default.
• W1982326629 cites W2014391890 @default.
• W1982326629 cites W2020416620 @default.
• W1982326629 cites W2029856340 @default.
• W1982326629 cites W2032011248 @default.
• W1982326629 cites W2050984751 @default.
• W1982326629 cites W2054031732 @default.
• W1982326629 cites W2062008959 @default.
• W1982326629 cites W2065047113 @default.
• W1982326629 cites W2066544749 @default.
• W1982326629 cites W2073070205 @default.
• W1982326629 cites W2081335997 @default.
• W1982326629 cites W2090110243 @default.
• W1982326629 cites W2147593455 @default.
• W1982326629 cites W2149352606 @default.
• W1982326629 cites W2291194041 @default.
• W1982326629 cites W4294216491 @default.
• W1982326629 doi "https://doi.org/10.1124/dmd.104.001321" @default.
• W1982326629 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15502008" @default.
• W1982326629 hasPublicationYear "2004" @default.
• W1982326629 type Work @default.
• W1982326629 sameAs 1982326629 @default.
• W1982326629 citedByCount "30" @default.
• W1982326629 countsByYear W19823266292012 @default.
• W1982326629 countsByYear W19823266292013 @default.
• W1982326629 countsByYear W19823266292014 @default.
• W1982326629 countsByYear W19823266292015 @default.
• W1982326629 countsByYear W19823266292016 @default.
• W1982326629 countsByYear W19823266292017 @default.
• W1982326629 countsByYear W19823266292018 @default.
• W1982326629 countsByYear W19823266292019 @default.
• W1982326629 countsByYear W19823266292020 @default.
• W1982326629 countsByYear W19823266292021 @default.
• W1982326629 countsByYear W19823266292022 @default.
• W1982326629 countsByYear W19823266292023 @default.
• W1982326629 crossrefType "journal-article" @default.
• W1982326629 hasAuthorship W1982326629A5001380867 @default.
• W1982326629 hasAuthorship W1982326629A5036496656 @default.
• W1982326629 hasAuthorship W1982326629A5049741600 @default.
• W1982326629 hasAuthorship W1982326629A5063054979 @default.
• W1982326629 hasAuthorship W1982326629A5074319401 @default.
• W1982326629 hasConcept C153911025 @default.
• W1982326629 hasConcept C178790620 @default.
• W1982326629 hasConcept C181199279 @default.
• W1982326629 hasConcept C185592680 @default.
• W1982326629 hasConcept C18903297 @default.
• W1982326629 hasConcept C2777289219 @default.
• W1982326629 hasConcept C2778004101 @default.
• W1982326629 hasConcept C2778951431 @default.
• W1982326629 hasConcept C2779054382 @default.
• W1982326629 hasConcept C2779478871 @default.
• W1982326629 hasConcept C2779907587 @default.
• W1982326629 hasConcept C526171541 @default.
• W1982326629 hasConcept C55493867 @default.
• W1982326629 hasConcept C71240020 @default.
• W1982326629 hasConcept C86803240 @default.
• W1982326629 hasConcept C87644729 @default.
• W1982326629 hasConceptScore W1982326629C153911025 @default.
• W1982326629 hasConceptScore W1982326629C178790620 @default.
• W1982326629 hasConceptScore W1982326629C181199279 @default.
• W1982326629 hasConceptScore W1982326629C185592680 @default.
• W1982326629 hasConceptScore W1982326629C18903297 @default.
• W1982326629 hasConceptScore W1982326629C2777289219 @default.
• W1982326629 hasConceptScore W1982326629C2778004101 @default.
• W1982326629 hasConceptScore W1982326629C2778951431 @default.
• W1982326629 hasConceptScore W1982326629C2779054382 @default.
• W1982326629 hasConceptScore W1982326629C2779478871 @default.
• W1982326629 hasConceptScore W1982326629C2779907587 @default.
• W1982326629 hasConceptScore W1982326629C526171541 @default.
• W1982326629 hasConceptScore W1982326629C55493867 @default.
• W1982326629 hasConceptScore W1982326629C71240020 @default.
• W1982326629 hasConceptScore W1982326629C86803240 @default.
• W1982326629 hasConceptScore W1982326629C87644729 @default.
• W1982326629 hasIssue "1" @default.
• W1982326629 hasLocation W19823266291 @default.
• W1982326629 hasLocation W19823266292 @default.
• W1982326629 hasOpenAccess W1982326629 @default.
• W1982326629 hasPrimaryLocation W19823266291 @default.
• W1982326629 hasRelatedWork W144983782 @default.
• W1982326629 hasRelatedWork W2083883121 @default.
• W1982326629 hasRelatedWork W2089340373 @default.
• W1982326629 hasRelatedWork W2123788796 @default.

• next