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• W1982328835 abstract "A new synthesis of the nucleoside analogue 3-deaza-2′-deoxycytidine is described. The N3-nitrogen of dC is involved in the central hydrogen bond of a dG-dC base pair. The relative importance of hydrogen bonding as a controlling factor in the activity of DNA polymerase is examined by studying both duplex stability and template effects for this dc3C nucleoside. Duplexes containing dG-dc3C base pairs were strongly destabilized while templates containing the analogue nucleoside were found to incorporate only the complementary dG triphosphate, similar to observations with templates containing the native 2′-deoxycytidine." @default.
• W1982328835 created "2016-06-24" @default.
• W1982328835 creator A5033260170 @default.
• W1982328835 creator A5055498462 @default.
• W1982328835 date "1999-10-01" @default.
• W1982328835 modified "2023-09-24" @default.
• W1982328835 title "Synthesis of the analogue nucleoside 3-deaza-2′-deoxycytidine and its template activity with DNA polymerase" @default.
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• W1982328835 doi "https://doi.org/10.1016/s0040-4020(99)00703-6" @default.
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