FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982330301> ?p ?o ?g. }

• W1982330301 abstract "Abstract Background Matriptase is a type II transmembrane serine protease that is found on the surfaces of epithelial cells and certain cancer cells. Matriptase has been implicated in the degradation of certain extracellular matrix components as well as the activation of various cellular proteins and proteases, including hepatocyte growth factor and urokinase. Sunflower trypsin inhibitor-1 (SFTI-1), a cyclic peptide inhibitor originally isolated from sunflower seeds, exhibits potent inhibitory activity toward matriptase. Results We have engineered and produced recombinant proteins of the matriptase protease domain, and have determined the crystal structures of the protease:SFTI-1 complex at 2.0 Å as well as the protease:benzamidine complex at 1.2 Å. These structures elaborate the structural basis of substrate selectivity of matriptase, and show that the matriptase S1 substrate specificity pocket is larger enough to allow movement of benzamidine inside the S1 pocket. Our study also reveals that SFTI-1 binds to matriptase in a way similar to its binding to trypsin despite the significantly different isoelectric points of the two proteins (5.6 vs. 8.2). Conclusions This work helps to define the structural basis of substrate specificity of matriptase and the interactions between the inhibitor and protease. The complex structure also provides a structural template for designing new SFTI-1 derivatives with better potency and selectivity against matriptase and other proteases." @default.
• W1982330301 created "2016-06-24" @default.
• W1982330301 creator A5025110808 @default.
• W1982330301 creator A5032740750 @default.
• W1982330301 creator A5047569518 @default.
• W1982330301 creator A5057729209 @default.
• W1982330301 creator A5079308758 @default.
• W1982330301 creator A5080112340 @default.
• W1982330301 creator A5083451056 @default.
• W1982330301 date "2011-06-22" @default.
• W1982330301 modified "2023-10-04" @default.
• W1982330301 title "Structure of catalytic domain of Matriptase in complex with Sunflower trypsin inhibitor-1" @default.
• W1982330301 cites W1917185230 @default.
• W1982330301 cites W1969754678 @default.
• W1982330301 cites W1971131900 @default.
• W1982330301 cites W1973834233 @default.
• W1982330301 cites W1986191025 @default.
• W1982330301 cites W1986424079 @default.
• W1982330301 cites W1991757994 @default.
• W1982330301 cites W1998761138 @default.
• W1982330301 cites W2001641653 @default.
• W1982330301 cites W2002449583 @default.
• W1982330301 cites W2015493192 @default.
• W1982330301 cites W2016382201 @default.
• W1982330301 cites W2020745334 @default.
• W1982330301 cites W2023213538 @default.
• W1982330301 cites W2029582401 @default.
• W1982330301 cites W2031635125 @default.
• W1982330301 cites W2031969028 @default.
• W1982330301 cites W2038372720 @default.
• W1982330301 cites W2038840577 @default.
• W1982330301 cites W2039135880 @default.
• W1982330301 cites W2040752945 @default.
• W1982330301 cites W2043895881 @default.
• W1982330301 cites W2052285025 @default.
• W1982330301 cites W2054525948 @default.
• W1982330301 cites W2067921100 @default.
• W1982330301 cites W2082547107 @default.
• W1982330301 cites W2091040928 @default.
• W1982330301 cites W2092571787 @default.
• W1982330301 cites W2094592690 @default.
• W1982330301 cites W2096914244 @default.
• W1982330301 cites W2097493124 @default.
• W1982330301 cites W2103100739 @default.
• W1982330301 cites W2107177621 @default.
• W1982330301 cites W2108038768 @default.
• W1982330301 cites W2114443373 @default.
• W1982330301 cites W2115573646 @default.
• W1982330301 cites W2119542456 @default.
• W1982330301 cites W2144081223 @default.
• W1982330301 cites W2144185179 @default.
• W1982330301 cites W2145208608 @default.
• W1982330301 cites W2154154560 @default.
• W1982330301 cites W2158264341 @default.
• W1982330301 cites W2168331945 @default.
• W1982330301 cites W2169362665 @default.
• W1982330301 cites W2169495823 @default.
• W1982330301 cites W2180229411 @default.
• W1982330301 doi "https://doi.org/10.1186/1472-6807-11-30" @default.
• W1982330301 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3141381" @default.
• W1982330301 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21693064" @default.
• W1982330301 hasPublicationYear "2011" @default.
• W1982330301 type Work @default.
• W1982330301 sameAs 1982330301 @default.
• W1982330301 citedByCount "49" @default.
• W1982330301 countsByYear W19823303012012 @default.
• W1982330301 countsByYear W19823303012013 @default.
• W1982330301 countsByYear W19823303012014 @default.
• W1982330301 countsByYear W19823303012015 @default.
• W1982330301 countsByYear W19823303012016 @default.
• W1982330301 countsByYear W19823303012017 @default.
• W1982330301 countsByYear W19823303012018 @default.
• W1982330301 countsByYear W19823303012019 @default.
• W1982330301 countsByYear W19823303012020 @default.
• W1982330301 countsByYear W19823303012021 @default.
• W1982330301 countsByYear W19823303012022 @default.
• W1982330301 countsByYear W19823303012023 @default.
• W1982330301 crossrefType "journal-article" @default.
• W1982330301 hasAuthorship W1982330301A5025110808 @default.
• W1982330301 hasAuthorship W1982330301A5032740750 @default.
• W1982330301 hasAuthorship W1982330301A5047569518 @default.
• W1982330301 hasAuthorship W1982330301A5057729209 @default.
• W1982330301 hasAuthorship W1982330301A5079308758 @default.
• W1982330301 hasAuthorship W1982330301A5080112340 @default.
• W1982330301 hasAuthorship W1982330301A5083451056 @default.
• W1982330301 hasBestOaLocation W19823303011 @default.
• W1982330301 hasConcept C141814087 @default.
• W1982330301 hasConcept C181199279 @default.
• W1982330301 hasConcept C182220744 @default.
• W1982330301 hasConcept C185592680 @default.
• W1982330301 hasConcept C2776351012 @default.
• W1982330301 hasConcept C2776714187 @default.
• W1982330301 hasConcept C2777807008 @default.
• W1982330301 hasConcept C2779288520 @default.
• W1982330301 hasConcept C2780340462 @default.
• W1982330301 hasConcept C55493867 @default.
• W1982330301 hasConcept C86803240 @default.
• W1982330301 hasConceptScore W1982330301C141814087 @default.
• W1982330301 hasConceptScore W1982330301C181199279 @default.
• W1982330301 hasConceptScore W1982330301C182220744 @default.

• next