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- W1982336282 abstract "Aim: To investigate the role of TNF-α promoter polymorphisms in the pathogenesis of Korean adult-onset Still's disease (AOSD) patients. Methods: DNA was isolated from blood samples collected from 58 patients with AOSD meeting Yamaguchi's criteria and 105 healthy controls. TNF-αpromoter polymorphisms at positions –1013, –863, –857, –308 were analysed by polymerase chain reaction-restriction fragment length polymorphism method. Genotype, allele, and estimated haplotype frequencies were compared between the AOSD group and controls. Results: The genotype, allele distributions, and estimated haplotype frequencies of the TNF-αpolymorphism between AOSD patients and controls were not significantly different. In addition, TNF-αpolymorphisms did not appear to have an effect on the disease course of the Korean AOSD patients. Conclusion: Genetic polymorphisms of TNF-αdo not play a significant role in the development or in their course of Korean AOSD patients." @default.
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- W1982336282 date "2008-08-01" @default.
- W1982336282 modified "2023-09-24" @default.
- W1982336282 title "TNF- polymorphisms in Korean adult-onset Still's disease patients" @default.
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- W1982336282 doi "https://doi.org/10.1111/j.1756-185x.2008.00351.x" @default.
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