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• W1982370510 abstract "The chemokine RANTES is a potent chemoattractant for eosinophils. RANTES is produced by lung epithelial cells during eosinophil‐rich inflammatory diseases such as asthma. In this study, we examined the effects of thiazolidinediones (TZD) on RANTES expression in a human lung epithelial cell line, A549. In A549 cells, interleukin‐1β and tumor necrosis factor‐α induced endogenous RANTES protein secretion, mRNA expression, and promoter activity. The TZD inhibited these effects. Our data indicate that the suppression of the expression of RANTES can be accomplished by TZD treatment, raising the possibility that TZD might be of therapeutic value in diseases such as asthma." @default.
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• W1982370510 date "1999-06-11" @default.
• W1982370510 modified "2023-10-14" @default.
• W1982370510 title "Thiazolidinedione inhibits production of RANTES in a cytokine-treated human lung epithelial cell line" @default.
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• W1982370510 doi "https://doi.org/10.1016/s0014-5793(99)00678-x" @default.
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