FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982372979> ?p ?o ?g. }

• W1982372979 endingPage "797" @default.
• W1982372979 startingPage "792" @default.
• W1982372979 abstract "Abstract Sublethal effects observed in fish exposed to environmental estrogens may be mediated via stimulation of cell death. To investigate whether cell death is induced in fish after chronic exposure to estrogenic chemicals, Japanese medaka ( Oryzias latipes ) were exposed from hatch until sexual maturity to 10 ng/L 17α‐ethinylestradiol (EE 2 ) or acetone solvent (control). Cell death was evaluated in blinded histological sections of whole medaka using terminal dideoxynucleotidyl‐mediated dUTP nick end‐labeling (TUNEL), which labels nuclei of cells containing apoptotic or necrotic (fragmented) DNA. The major impact of EE 2 exposure in both male and female medaka was to significantly increase the number of TUNEL‐positive hepatocytes and kidney tubule cells compared to control. Cell morphology was consistent with apoptosis in the liver and cloudy swelling or necrosis in the tubule cells. The number of TUNEL‐positive interstitial (hematopoietic) and glomerular cells was significantly greater in the kidneys of EE 2 ‐exposed male, but not female, medaka. The EE 2 exposure also significantly increased the number of TUNEL‐positive testicular cells in medaka compared to corresponding controls, namely Leydig cells, Sertoli cells, spermatocytes, and spermatids. In medaka with gonadal intersex, areas of fibrosis and areas containing female gonadal cells were relatively unstained with TUNEL. No effect of EE 2 exposure on the number of TUNEL‐positive ovarian somatic cells or on the rate of female ovarian follicle atresia was found. These results suggest that chronic exposure to EE 2 in medaka is hepatotoxic and nephrotoxic in both sexes, whereas gonadal toxicity is specific to males." @default.
• W1982372979 created "2016-06-24" @default.
• W1982372979 creator A5007839244 @default.
• W1982372979 creator A5021121907 @default.
• W1982372979 creator A5042967044 @default.
• W1982372979 creator A5054142482 @default.
• W1982372979 date "2004-03-01" @default.
• W1982372979 modified "2023-10-11" @default.
• W1982372979 title "INCREASED KIDNEY, LIVER, AND TESTICULAR CELL DEATH AFTER CHRONIC EXPOSURE TO 17α-ETHINYLESTRADIOL IN MEDAKA (ORYZIAS LATIPES)" @default.
• W1982372979 cites W1982099654 @default.
• W1982372979 cites W1994349548 @default.
• W1982372979 cites W1998846649 @default.
• W1982372979 cites W2015205153 @default.
• W1982372979 cites W2015712723 @default.
• W1982372979 cites W2019306802 @default.
• W1982372979 cites W2036389563 @default.
• W1982372979 cites W2039122086 @default.
• W1982372979 cites W2046848104 @default.
• W1982372979 cites W2049447685 @default.
• W1982372979 cites W2053322034 @default.
• W1982372979 cites W2059174999 @default.
• W1982372979 cites W2090778700 @default.
• W1982372979 cites W2092115674 @default.
• W1982372979 cites W2120356484 @default.
• W1982372979 cites W2138302361 @default.
• W1982372979 cites W2143853738 @default.
• W1982372979 cites W2144542356 @default.
• W1982372979 cites W2157414721 @default.
• W1982372979 cites W2170238898 @default.
• W1982372979 cites W225930094 @default.
• W1982372979 doi "https://doi.org/10.1897/02-570" @default.
• W1982372979 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15285374" @default.
• W1982372979 hasPublicationYear "2004" @default.
• W1982372979 type Work @default.
• W1982372979 sameAs 1982372979 @default.
• W1982372979 citedByCount "38" @default.
• W1982372979 countsByYear W19823729792012 @default.
• W1982372979 countsByYear W19823729792013 @default.
• W1982372979 countsByYear W19823729792014 @default.
• W1982372979 countsByYear W19823729792015 @default.
• W1982372979 countsByYear W19823729792016 @default.
• W1982372979 countsByYear W19823729792017 @default.
• W1982372979 countsByYear W19823729792018 @default.
• W1982372979 countsByYear W19823729792020 @default.
• W1982372979 countsByYear W19823729792021 @default.
• W1982372979 countsByYear W19823729792022 @default.
• W1982372979 crossrefType "journal-article" @default.
• W1982372979 hasAuthorship W1982372979A5007839244 @default.
• W1982372979 hasAuthorship W1982372979A5021121907 @default.
• W1982372979 hasAuthorship W1982372979A5042967044 @default.
• W1982372979 hasAuthorship W1982372979A5054142482 @default.
• W1982372979 hasConcept C123765429 @default.
• W1982372979 hasConcept C126322002 @default.
• W1982372979 hasConcept C134018914 @default.
• W1982372979 hasConcept C16685009 @default.
• W1982372979 hasConcept C190283241 @default.
• W1982372979 hasConcept C196795494 @default.
• W1982372979 hasConcept C2777289358 @default.
• W1982372979 hasConcept C2777736315 @default.
• W1982372979 hasConcept C2778575703 @default.
• W1982372979 hasConcept C2781068068 @default.
• W1982372979 hasConcept C2909208804 @default.
• W1982372979 hasConcept C31573885 @default.
• W1982372979 hasConcept C505870484 @default.
• W1982372979 hasConcept C55493867 @default.
• W1982372979 hasConcept C71315377 @default.
• W1982372979 hasConcept C71924100 @default.
• W1982372979 hasConcept C86803240 @default.
• W1982372979 hasConceptScore W1982372979C123765429 @default.
• W1982372979 hasConceptScore W1982372979C126322002 @default.
• W1982372979 hasConceptScore W1982372979C134018914 @default.
• W1982372979 hasConceptScore W1982372979C16685009 @default.
• W1982372979 hasConceptScore W1982372979C190283241 @default.
• W1982372979 hasConceptScore W1982372979C196795494 @default.
• W1982372979 hasConceptScore W1982372979C2777289358 @default.
• W1982372979 hasConceptScore W1982372979C2777736315 @default.
• W1982372979 hasConceptScore W1982372979C2778575703 @default.
• W1982372979 hasConceptScore W1982372979C2781068068 @default.
• W1982372979 hasConceptScore W1982372979C2909208804 @default.
• W1982372979 hasConceptScore W1982372979C31573885 @default.
• W1982372979 hasConceptScore W1982372979C505870484 @default.
• W1982372979 hasConceptScore W1982372979C55493867 @default.
• W1982372979 hasConceptScore W1982372979C71315377 @default.
• W1982372979 hasConceptScore W1982372979C71924100 @default.
• W1982372979 hasConceptScore W1982372979C86803240 @default.
• W1982372979 hasIssue "3" @default.
• W1982372979 hasLocation W19823729791 @default.
• W1982372979 hasLocation W19823729792 @default.
• W1982372979 hasOpenAccess W1982372979 @default.
• W1982372979 hasPrimaryLocation W19823729791 @default.
• W1982372979 hasRelatedWork W1979589658 @default.
• W1982372979 hasRelatedWork W2013076294 @default.
• W1982372979 hasRelatedWork W2042670436 @default.
• W1982372979 hasRelatedWork W2071967854 @default.
• W1982372979 hasRelatedWork W2084719009 @default.
• W1982372979 hasRelatedWork W2091631118 @default.
• W1982372979 hasRelatedWork W2122696678 @default.
• W1982372979 hasRelatedWork W2148182143 @default.

• next