FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982373586> ?p ?o ?g. }

• W1982373586 endingPage "140" @default.
• W1982373586 startingPage "131" @default.
• W1982373586 abstract "Rheumatoid factors (RF) are autoantibodies with specificity for the constant regions of IgG molecules. They are found in several immunopathological diseases. The mechanism(s) by which these autoantibodies are produced is largely unknown. We have previously shown that a single injection of RF-like immune complexes (ICs) into mice selectively induced an intense IgG1-antibody production with RF activity. This response was sustained for several months and did not resemble a conventional immune response to an antigen or other immune complexes. In the present study, we sought to elucidate the mechanism for the IgG1 RF response to RF-like ICs. Therefore, the roles of CD4+T cells, complement and Fcγ receptors were analysed. In order to characterize the role of CD4+T cells, RF-like induced IgG1-RF production was analysed in NZB mice treated with a monoclonal antibody (mAb) against the CD4 molecule, which resulted in complete abrogation of IgG1 RF production. To evaluate the importance of FcγRs, the effect of RF-like ICs was tested in mice deficient for RFγRI/III. A significant decrease in the numbers of IgG1 antibody secreting cells, as well as in serum IgG1 RF levels, was found in the deficient mice, as compared with their normal outbred littermates. The role of complement in RF-like ICs mediated IgG1 RF was tested in complement depleted NZB mice, using Cobra venom factor. The IgG1 RF response in complement depleted and intact mice was comparable. Thus, our results demonstrate that RF-like immune complexes selectively induce an FcγR-dependent, complement independent antibody response in mice." @default.
• W1982373586 created "2016-06-24" @default.
• W1982373586 creator A5019865629 @default.
• W1982373586 creator A5039353263 @default.
• W1982373586 creator A5066073113 @default.
• W1982373586 date "1998-04-01" @default.
• W1982373586 modified "2023-10-16" @default.
• W1982373586 title "Induction of IgG Rheumatoid Factor (RF) Production by Antibody–antibody (RF-like) Immune Complexes: the Role of T cells, Complement and Fcγ Receptors" @default.
• W1982373586 cites W1501734887 @default.
• W1982373586 cites W1606369440 @default.
• W1982373586 cites W1628687528 @default.
• W1982373586 cites W1964706714 @default.
• W1982373586 cites W1970794864 @default.
• W1982373586 cites W1972108403 @default.
• W1982373586 cites W1983940041 @default.
• W1982373586 cites W2000784101 @default.
• W1982373586 cites W2001473575 @default.
• W1982373586 cites W2012177306 @default.
• W1982373586 cites W2016833576 @default.
• W1982373586 cites W2019712600 @default.
• W1982373586 cites W2021044670 @default.
• W1982373586 cites W2032679326 @default.
• W1982373586 cites W2041729262 @default.
• W1982373586 cites W2044220528 @default.
• W1982373586 cites W2059234076 @default.
• W1982373586 cites W2060248408 @default.
• W1982373586 cites W2060894950 @default.
• W1982373586 cites W2062020700 @default.
• W1982373586 cites W2063797375 @default.
• W1982373586 cites W2096287486 @default.
• W1982373586 cites W2097386856 @default.
• W1982373586 cites W2098091873 @default.
• W1982373586 cites W2099486151 @default.
• W1982373586 cites W2117537205 @default.
• W1982373586 cites W2118282518 @default.
• W1982373586 cites W2121458534 @default.
• W1982373586 cites W2129738736 @default.
• W1982373586 cites W2143896178 @default.
• W1982373586 cites W2150844359 @default.
• W1982373586 cites W2165371901 @default.
• W1982373586 cites W2177385981 @default.
• W1982373586 cites W4249736906 @default.
• W1982373586 cites W4313313418 @default.
• W1982373586 doi "https://doi.org/10.1006/jaut.1998.0189" @default.
• W1982373586 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9650092" @default.
• W1982373586 hasPublicationYear "1998" @default.
• W1982373586 type Work @default.
• W1982373586 sameAs 1982373586 @default.
• W1982373586 citedByCount "10" @default.
• W1982373586 countsByYear W19823735862020 @default.
• W1982373586 crossrefType "journal-article" @default.
• W1982373586 hasAuthorship W1982373586A5019865629 @default.
• W1982373586 hasAuthorship W1982373586A5039353263 @default.
• W1982373586 hasAuthorship W1982373586A5066073113 @default.
• W1982373586 hasConcept C111684460 @default.
• W1982373586 hasConcept C153911025 @default.
• W1982373586 hasConcept C159654299 @default.
• W1982373586 hasConcept C163764329 @default.
• W1982373586 hasConcept C170493617 @default.
• W1982373586 hasConcept C185592680 @default.
• W1982373586 hasConcept C203014093 @default.
• W1982373586 hasConcept C2776232647 @default.
• W1982373586 hasConcept C2778474638 @default.
• W1982373586 hasConcept C2779931124 @default.
• W1982373586 hasConcept C2780898057 @default.
• W1982373586 hasConcept C55493867 @default.
• W1982373586 hasConcept C86803240 @default.
• W1982373586 hasConcept C8891405 @default.
• W1982373586 hasConceptScore W1982373586C111684460 @default.
• W1982373586 hasConceptScore W1982373586C153911025 @default.
• W1982373586 hasConceptScore W1982373586C159654299 @default.
• W1982373586 hasConceptScore W1982373586C163764329 @default.
• W1982373586 hasConceptScore W1982373586C170493617 @default.
• W1982373586 hasConceptScore W1982373586C185592680 @default.
• W1982373586 hasConceptScore W1982373586C203014093 @default.
• W1982373586 hasConceptScore W1982373586C2776232647 @default.
• W1982373586 hasConceptScore W1982373586C2778474638 @default.
• W1982373586 hasConceptScore W1982373586C2779931124 @default.
• W1982373586 hasConceptScore W1982373586C2780898057 @default.
• W1982373586 hasConceptScore W1982373586C55493867 @default.
• W1982373586 hasConceptScore W1982373586C86803240 @default.
• W1982373586 hasConceptScore W1982373586C8891405 @default.
• W1982373586 hasIssue "2" @default.
• W1982373586 hasLocation W19823735861 @default.
• W1982373586 hasLocation W19823735862 @default.
• W1982373586 hasOpenAccess W1982373586 @default.
• W1982373586 hasPrimaryLocation W19823735861 @default.
• W1982373586 hasRelatedWork W1606219045 @default.
• W1982373586 hasRelatedWork W165485614 @default.
• W1982373586 hasRelatedWork W1980206759 @default.
• W1982373586 hasRelatedWork W2001473575 @default.
• W1982373586 hasRelatedWork W2035881973 @default.
• W1982373586 hasRelatedWork W2041901455 @default.
• W1982373586 hasRelatedWork W2043104746 @default.
• W1982373586 hasRelatedWork W2519199594 @default.
• W1982373586 hasRelatedWork W2967565826 @default.
• W1982373586 hasRelatedWork W2188190763 @default.
• W1982373586 hasVolume "11" @default.

• next