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- W1982406824 abstract "Most current knowledge about DNA polymerase zeta (pol zeta) comes from studies of the enzyme in the budding yeast Saccharomyces cerevisiae, where pol zeta consists of a complex of the catalytic subunit Rev3 with Rev7, which associates with Rev1. Most spontaneous and induced mutagenesis in yeast is dependent on these gene products, and yeast pol zeta can mediate translesion DNA synthesis past some adducts in DNA templates. Study of the homologous gene products in higher eukaryotes is in a relatively early stage, but additional functions for the eukaryotic proteins are already apparent. Suppression of vertebrate REV3L function not only reduces induced point mutagenesis but also causes larger-scale genome instability by raising the frequency of spontaneous chromosome translocations. Disruption of Rev3L function is tolerated in Drosophila, Arabidopsis, and in vertebrate cell lines under some conditions, but is incompatible with mouse embryonic development. Functions for REV3L and REV7(MAD2B) in higher eukaryotes have been suggested not only in translesion DNA synthesis but also in some forms of homologous recombination, repair of interstrand DNA crosslinks, somatic hypermutation of immunoglobulin genes and cell-cycle control. This review discusses recent developments in these areas." @default.
- W1982406824 created "2016-06-24" @default.
- W1982406824 creator A5044093871 @default.
- W1982406824 creator A5053090521 @default.
- W1982406824 creator A5064044884 @default.
- W1982406824 creator A5065003651 @default.
- W1982406824 date "2007-12-24" @default.
- W1982406824 modified "2023-10-07" @default.
- W1982406824 title "DNA polymerase zeta (pol ζ) in higher eukaryotes" @default.
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- W1982406824 doi "https://doi.org/10.1038/cr.2007.117" @default.