FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982413007> ?p ?o ?g. }

• W1982413007 endingPage "4129" @default.
• W1982413007 startingPage "4120" @default.
• W1982413007 abstract "Our recent study showed critical roles of Dmp1 as a sensor of oncogenic Ras, HER2/neu signaling and activation of the Arf-p53 pathway. To elucidate the role of human DMP1 (hDMP1) in breast cancer, one hundred and ten pairs of human breast cancer specimen were studied for the alterations of the hDMP1-ARF-Hdm2-p53 pathway with follow up of clinical outcomes. Loss of heterozygosity (LOH) of the hDMP1 locus was found in 42% of human breast carcinomas, while that of INK4a/ARF and p53 were found in 20 and 34%, respectively. Hdm2 amplification was found in 13% of the same sample, which was found independently of LOH for hDMP1. Conversely, LOH for hDMP1 was found in mutually exclusive fashion with that of INK4a/ARF and p53, and was associated with low Ki67 index and diploid karyotype. Consistently, LOH for hDMP1 was associated with luminal A category and longer relapse-free survival, while that of p53 was associated with non-luminal A and shorter survival. Thus, loss of hDMP1 could define a new disease category associated with prognosis of breast cancer patients. Human breast epithelial cells/cancer cells with wild-type p53 were sensitive to growth inhibition by activated Dmp1:ER while those that delete p14(ARF) or p53, and/or Hdm2 amplification showed partial or nearly complete resistance, indicating that p53 is a critical target for hDMP1 to exhibit its biological activity." @default.
• W1982413007 created "2016-06-24" @default.
• W1982413007 creator A5001168379 @default.
• W1982413007 creator A5007062346 @default.
• W1982413007 creator A5013472413 @default.
• W1982413007 creator A5024804165 @default.
• W1982413007 creator A5027595689 @default.
• W1982413007 creator A5028202646 @default.
• W1982413007 creator A5051732862 @default.
• W1982413007 creator A5064526242 @default.
• W1982413007 creator A5085840629 @default.
• W1982413007 creator A5087055892 @default.
• W1982413007 date "2012-10-08" @default.
• W1982413007 modified "2023-10-06" @default.
• W1982413007 title "Prognostic value of the hDMP1-ARF-Hdm2-p53 pathway in breast cancer" @default.
• W1982413007 cites W1565276921 @default.
• W1982413007 cites W1919339122 @default.
• W1982413007 cites W1966714888 @default.
• W1982413007 cites W1968075505 @default.
• W1982413007 cites W1973677548 @default.
• W1982413007 cites W1991586667 @default.
• W1982413007 cites W2003399563 @default.
• W1982413007 cites W2020584741 @default.
• W1982413007 cites W2022792299 @default.
• W1982413007 cites W2023200343 @default.
• W1982413007 cites W2042542808 @default.
• W1982413007 cites W2047622651 @default.
• W1982413007 cites W2060989729 @default.
• W1982413007 cites W2066874631 @default.
• W1982413007 cites W2067133313 @default.
• W1982413007 cites W2069059286 @default.
• W1982413007 cites W2071906362 @default.
• W1982413007 cites W2076356585 @default.
• W1982413007 cites W2085117140 @default.
• W1982413007 cites W2091997396 @default.
• W1982413007 cites W2102680618 @default.
• W1982413007 cites W2103237568 @default.
• W1982413007 cites W2120704865 @default.
• W1982413007 cites W2121792822 @default.
• W1982413007 cites W2123283129 @default.
• W1982413007 cites W2127057139 @default.
• W1982413007 cites W2146287151 @default.
• W1982413007 cites W2146620892 @default.
• W1982413007 cites W2147859798 @default.
• W1982413007 cites W2166781496 @default.
• W1982413007 cites W2185924837 @default.
• W1982413007 cites W2314318352 @default.
• W1982413007 doi "https://doi.org/10.1038/onc.2012.423" @default.
• W1982413007 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3742602" @default.
• W1982413007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23045280" @default.
• W1982413007 hasPublicationYear "2012" @default.
• W1982413007 type Work @default.
• W1982413007 sameAs 1982413007 @default.
• W1982413007 citedByCount "31" @default.
• W1982413007 countsByYear W19824130072014 @default.
• W1982413007 countsByYear W19824130072015 @default.
• W1982413007 countsByYear W19824130072016 @default.
• W1982413007 countsByYear W19824130072017 @default.
• W1982413007 countsByYear W19824130072018 @default.
• W1982413007 countsByYear W19824130072019 @default.
• W1982413007 countsByYear W19824130072020 @default.
• W1982413007 countsByYear W19824130072021 @default.
• W1982413007 countsByYear W19824130072022 @default.
• W1982413007 crossrefType "journal-article" @default.
• W1982413007 hasAuthorship W1982413007A5001168379 @default.
• W1982413007 hasAuthorship W1982413007A5007062346 @default.
• W1982413007 hasAuthorship W1982413007A5013472413 @default.
• W1982413007 hasAuthorship W1982413007A5024804165 @default.
• W1982413007 hasAuthorship W1982413007A5027595689 @default.
• W1982413007 hasAuthorship W1982413007A5028202646 @default.
• W1982413007 hasAuthorship W1982413007A5051732862 @default.
• W1982413007 hasAuthorship W1982413007A5064526242 @default.
• W1982413007 hasAuthorship W1982413007A5085840629 @default.
• W1982413007 hasAuthorship W1982413007A5087055892 @default.
• W1982413007 hasBestOaLocation W19824130071 @default.
• W1982413007 hasConcept C104317684 @default.
• W1982413007 hasConcept C121608353 @default.
• W1982413007 hasConcept C143589142 @default.
• W1982413007 hasConcept C180754005 @default.
• W1982413007 hasConcept C2778264664 @default.
• W1982413007 hasConcept C502942594 @default.
• W1982413007 hasConcept C530470458 @default.
• W1982413007 hasConcept C54355233 @default.
• W1982413007 hasConcept C555283112 @default.
• W1982413007 hasConcept C84597430 @default.
• W1982413007 hasConcept C86803240 @default.
• W1982413007 hasConceptScore W1982413007C104317684 @default.
• W1982413007 hasConceptScore W1982413007C121608353 @default.
• W1982413007 hasConceptScore W1982413007C143589142 @default.
• W1982413007 hasConceptScore W1982413007C180754005 @default.
• W1982413007 hasConceptScore W1982413007C2778264664 @default.
• W1982413007 hasConceptScore W1982413007C502942594 @default.
• W1982413007 hasConceptScore W1982413007C530470458 @default.
• W1982413007 hasConceptScore W1982413007C54355233 @default.
• W1982413007 hasConceptScore W1982413007C555283112 @default.
• W1982413007 hasConceptScore W1982413007C84597430 @default.
• W1982413007 hasConceptScore W1982413007C86803240 @default.
• W1982413007 hasIssue "35" @default.

• next