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- W1982413261 abstract "Microsomal NADPH-cytochrome P-450 reductase (EC 1.6.2.4) and xanthine oxidase (EC 1.2.3.2) catalyzed the activation of antitumor antibiotic, mitomycin C, under anaerobic conditions. Under aerobic conditions, NADPH-cytochrome P-450 reductase catalyzed the quinone structure containing antitumor compound-dependent NADPH oxidation. With our previous results, the direct contribution of NADPH-cytochrome P-450 reductase to the quinone drug metabolism was generalized." @default.
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- W1982413261 date "1979-01-01" @default.
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- W1982413261 title "Activation of mitomycin C and quinone drug metabolism by NADPH-cytochrome P-450 reductase." @default.
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- W1982413261 doi "https://doi.org/10.1248/bpb1978.2.407" @default.
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