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- W1982438527 abstract "A human astrocytoma cell line, U373, and its subclones showed a high proliferative response to IL1α or IL1β with concomitant IL6 production and IL6 mRNA accumulation. IL1 itself raised neither the cAMP level nor the intracellular Ca2+ level nor did it induce phosphatidylinositol (PI) breakdown. Chorela toxin (CT) and pertussis toxin (PT)-pretreatment markedly inhibited IL1-induced proliferation, while CT enhanced IL1-induced IL6 mRNA expression significantly. Drugs raising cellular cAMP level or cAMP analogues augmented IL1-mediated IL6 mRNA expression but much less. Although cAMP is not directly involved in the IL1 action, cAMP thus has a modulatory effect on IL1-mediated IL6 gene activation." @default.
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- W1982438527 date "1990-03-01" @default.
- W1982438527 modified "2023-09-25" @default.
- W1982438527 title "IL1 induces proliferation and IL6 mRNA expression in a human astrocytoma cell line: Positive and negative modulation by chorela toxin and cAMP" @default.
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- W1982438527 doi "https://doi.org/10.1016/0006-291x(90)90657-9" @default.
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