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• W1982440868 abstract "Due to a recent breakthrough in three-dimensional reconstruction techniques, macromolecules or macromolecular assemblies occurs in non-crystalline form as ‘single particles’ can now be reconstructed with high statistical deformation from low-dose electron micrographs. The new technique has been used thus far to determine the structure of the 50S ribosomal subunit and the 70S ribosome from Escherichia coli as well as the 40S subunit and the 80S ribosome from rabbit reticulocytes. The technique will also enable the mapping of surface ligands through direct three-dimensional visualization, and can thus be expected to make a major contribution to an understanding of the function of ribosomes, and potentially many other important macromolecules assemblies." @default.
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• W1982440868 date "1988-04-01" @default.
• W1982440868 modified "2023-09-25" @default.
• W1982440868 title "A new non-crystallographic image-processing technique reveals the architecture of ribosomes" @default.
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• W1982440868 doi "https://doi.org/10.1016/0968-0004(88)90063-1" @default.
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