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- W1982461801 abstract "The scale-up of Streptomyces hygroscopicus subsp. aureolacrimosus in submerged culture and the production of milbemycin, a 16-membered macrolide pesticidal antibiotic, are described. The primary scale-up of a dissolved oxygen (DO)-stat culture to 12000 dm3 failed for milbemycin production, when only agitation was used for DO control. Whenever production deteriorated in a plant-scale fermenter, several symptoms (such as morphological changes) were observed, termed SUDS (Scale-Up-Deteriorated production Syndrome). A series of experiments generating SUDS intentionally, replacing agitation-increasing with aeration-increasing operation, and examining internal pressure or temperature effects indicated alternative DO control procedures to prevent SUDS. Among these procedures investigated, a sole procedure resulted in successful scale-up to plant-scale (6000 and 12000 dm3). In the control procedure, these control variables were employed in the order of internal pressure, aeration, agitation and culture temperature. © 1997 SCI" @default.
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- W1982461801 date "1997-10-01" @default.
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- W1982461801 title "Scale-up Production of Milbemycin byStreptomyces hygroscopicus subsp.aureolacrimosus with Control of Internal Pressure, Temperature, Aeration and Agitation" @default.
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- W1982461801 doi "https://doi.org/10.1002/(sici)1097-4660(199710)70:2<179::aid-jctb741>3.0.co;2-a" @default.
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