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• W1982472387 abstract "<i>Purpose:</i> The 3 carotenoids lutein, zeaxanthin, and <i>meso</i>-zeaxanthin, which account for the ‘yellow spot’ at the macula and which are referred to as macular pigment (MP), are believed to play a role in visual function and protect against age-related macular degeneration (AMD) via their optical and antioxidant properties. This study was undertaken to compare MP optical density (MPOD) in a population aged ≧50 years with MPOD values from a normative database of subjects aged 18–60 years. <i>Methods:</i> Seventy-nine subjects were recruited into this pilot study (The Irish Longitudinal Study on Ageing-TILDA). MPOD was measured using heterochromatic flicker photometry. Retinal fundus photographs, lifestyle data and general health data, were also obtained. <i>Results:</i> The mean ± SD age of the 79 subjects recruited into this study was 65 ± 11 years. There was a moderate, but statistically significant, age-related decline in MPOD at 0.5° in the TILDA data (r = –0.251, p = 0.045), which remained upon merging with a normative database of an additional 462 subjects aged between 18 and 67 years (r = –0.179, p = 0.000). <i>Conclusions:</i> We report an inverse association between MPOD and increasing age. Longitudinal data in a larger cohort of participants are required to satisfactorily investigate the relationship between the optical density of this pigment and age, and with risk for development and/or progression of AMD. This pilot study represents a first step in this endeavour." @default.
• W1982472387 created "2016-06-24" @default.
• W1982472387 creator A5019717537 @default.
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• W1982472387 date "2010-01-01" @default.
• W1982472387 modified "2023-09-25" @default.
• W1982472387 title "Macular Pigment Optical Density in an Ageing Irish Population: The Irish Longitudinal Study on Ageing" @default.
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• W1982472387 doi "https://doi.org/10.1159/000315531" @default.
• W1982472387 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20516725" @default.
• W1982472387 hasPublicationYear "2010" @default.
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