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- W1982477881 abstract "The formation of antigonadotrophic substances have resulted from the prolonged administration of all the gonadotrophins which have been studied. Though for some time it was supposed that antihormones were not formed against homologous gonadotrophins, Katzman et al. (1947) demonstrated clearly the formation of antigonadotrophins in sheep after treatment for approximately one year with sheep pituitary gonadotrophic extracts. As it is doubtful if antigonadotrophins are formed against endogenous gonadotrophins, it is probable that the chemical treatment to which the extracts have been subjected has made the gonadotrophins antigenic. Frequently, the sera of animals receiving chronic treatment with gonadotrophins may display progonadotrophic activity before antigonadotrophic responses are obtained (Rowlands, 1937; Thompson, 1937; Katzman et al., 1947; Marvin & Meyer, 1943); further, a given sample of serum may augment at low dosages and inhibit if higher levels of the serum are administered with the gonadotrophin. Sera from certain patients who have not been" @default.
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- W1982477881 date "1957-11-01" @default.
- W1982477881 modified "2023-09-27" @default.
- W1982477881 title "STUDIES ON ANTIGONADOTROPHINS WITH EMPHASIS ON THEIR FORMATION IN CATTLE" @default.
- W1982477881 doi "https://doi.org/10.1530/acta.0.0260286" @default.
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