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- W1982478049 abstract "Acrolein, a short-chain aldehyde encountered as a component of tobacco smoke and as a ubiquitous environmental contaminant, was tested for its toxic and mutagenic effects toward human fibroblast cells. We found that human cells characterized by a deficiency in DNA repair (cells from xeroderma pigmentosum (XP) patients) were much more sensitive (D37 ≌ 0.25 μM) to the cytotoxic effects of acrolein than were cells from normal individuals (D37 ≌ 0.8 μM). Acrolein was also strongly mutagenic to the XP cells (a dose response was observed between 0.2 and 0.8 μM acrolein); however acrolein did not induce an increase in the mutant frequency of normal fibroblasts. Possible reasons for this apparent lack of mutagenicity in normal human cells are discussed." @default.
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- W1982478049 date "1988-09-01" @default.
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- W1982478049 title "Mutagenesis of xeroderma pigmentosum fibroblasts by acrolein" @default.
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- W1982478049 doi "https://doi.org/10.1016/0165-7992(88)90104-2" @default.
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