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• W1982479969 abstract "The extracellular isoform of superoxide dismutase (EC-SOD, Sod3) plays a protective role against various diseases and injuries mediated by oxidative stress. To investigate the pathophysiological roles of EC-SOD, we generated tetracycline-inducible Sod3 transgenic mice and directed the tissue-specific expression of transgenes by crossing Sod3 transgenic mice with tissue-specific transactivator transgenics. Double transgenic mice with liver-specific expression of Sod3 showed increased EC-SOD levels predominantly in the plasma as the circulating form, whereas double transgenic mice with neuronal-specific expression expressed higher levels of EC-SOD in hippocampus and cortex with intact EC-SOD as the dominant form. EC-SOD protein levels also correlated well with increased SOD activities in double transgenic mice. In addition to enabling tissue-specific expression, the transgene expression can be quickly turned on and off by doxycycline supplementation in the mouse chow. This mouse model, thus, provides the flexibility for on-off control of transgene expression in multiple target tissues." @default.
• W1982479969 created "2016-06-24" @default.
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• W1982479969 date "2009-03-01" @default.
• W1982479969 modified "2023-09-23" @default.
• W1982479969 title "A new mouse model for temporal- and tissue-specific control of extracellular superoxide dismutase" @default.
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• W1982479969 doi "https://doi.org/10.1002/dvg.20470" @default.
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