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- W1982481952 abstract "The effect of the oral administration of oxyphenbutazone (Tandearil) on tumor growth and the levels of the seromucoid protein and seromucoid-bound carbohydrates of rats bearing Walker 256 has been studied. Oxyphenbutazone was administered at two dose levels, namely 60 mg/kg per day and 100 mg/kg per day. The anticipated elevation of seromucoid protein and seromucoid-bound carbohydrates was observed in untreated tumor-bearing rats. Oxyphenbutazone treatment suppressed the initial response of seromucoid protein and seromucoid-bound carbohydrate in tumor-bearing rats such that no significant elevation occurred over levels recorded for untreated nontumor-bearing rats for the first 8 days following transplantation. After 8 days the levels of seromucoid protein and seromucoid-bound carbohydrate were elevated in treated tumor-bearing animals as compared with untreated nontumor-bearing controls although the magnitude of the elevation was significantly less than that observed in untreated tumor-bearing animals.Oxyphenbutazone at an oral dose of 100 mg/kg per day proved toxic to the adult male rat. Toxicity was manifested by weight loss and occasionally by a fatal hemorrhagic gastritis.Tumors regressed in oxyphenbutazone-treated animals, and survival times of animals treated with oxyphenbutazone at 60 mg/kg per day exceeded those of comparable untreated tumor-bearing animals. In addition, treated animals were free of apparent malignant disease at the completion of the study." @default.
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- W1982481952 date "1971-12-01" @default.
- W1982481952 modified "2023-09-23" @default.
- W1982481952 title "The Effect of Oral Oxyphenbutazone (Tandearil) on Tumor Growth and the Level of the Seromucoid Fraction in Rats Bearing Walker 256 Carcinoma" @default.
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- W1982481952 doi "https://doi.org/10.1139/y71-152" @default.
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