FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982482362> ?p ?o ?g. }

• W1982482362 endingPage "1745" @default.
• W1982482362 startingPage "1734" @default.
• W1982482362 abstract "An applicator designed for rectal delivery of microbicides was tested for acceptability by 95 young men who have sex with men, who self-administered 4 mL of placebo gel prior to receptive anal intercourse over 90 days. Subsequently, 24 of the participants self-administered rectally 4 mL of tenofovir or placebo gel over 7 days using a vaginal applicator, and compared both applicators on a Likert scale of 1–10, with 10 the highest rating. Participants reported high likelihood to use either applicator in the future (mean scores 9.3 and 8.8 respectively, p = ns). Those who tested both liked the vaginal applicator significantly more than the rectal applicator (7.8 vs. 5.2, p = 0.003). Improvements in portability, conspicuousness, aesthetics, tip comfort, product assembly and packaging were suggested for both. This rectal-specific applicator was not superior to a vaginal applicator. While likelihood of future use is reportedly high, factors that decrease acceptability may erode product use over time in clinical trials. Further attention is needed to develop user-friendly, quick-acting rectal microbicide delivery systems. Un aplicador diseñado para administrar los microbicidas rectales fue probado para determinar su aceptabilidad por 95 hombres jóvenes que tienen sexo con hombres, quienes auto-administraron 4 mL de un gel placebo antes del sexo anal receptivo durante 90 días. Posteriormente, 24 de los participantes auto-administraron rectalmente 4 mL de un gel tenofovir o placebo durante 7 días usando un aplicador vaginal, y compararon ambos aplicadores en una escala Likert de 1 a 10, 10 siendo la calificación más alta. Los participantes reportaron alta probabilidad de usar cualquiera de los dos aplicadores en el futuro (calificación media 9.3 y 8.8, respectivamente, p = ns). A los que probaron ambos les gustó significativamente más el aplicador vaginal que el rectal (7.8 vs. 5.2, p = 0.003). Se dieron sugerencias para mejorar la portabilidad, visibilidad, estética, comodidad de la punta, ensamblaje y embalaje de ambos aplicadores. Este aplicador específicamente para uso rectal no fue superior al aplicador vaginal. Aunque se reportó una alta probabilidad de uso en el futuro, los factores que disminuyen la aceptabilidad podrían afectar el uso del producto con el tiempo en los ensayos clínicos. Se necesita enfocar más atención en el desarrollo de sistemas de administración de microbicidas rectales que sean fáciles de usar y rápidas." @default.
• W1982482362 created "2016-06-24" @default.
• W1982482362 creator A5009903397 @default.
• W1982482362 creator A5011885117 @default.
• W1982482362 creator A5012552931 @default.
• W1982482362 creator A5018723426 @default.
• W1982482362 creator A5025150770 @default.
• W1982482362 creator A5026208580 @default.
• W1982482362 creator A5030305126 @default.
• W1982482362 creator A5046912221 @default.
• W1982482362 creator A5054402928 @default.
• W1982482362 creator A5067046703 @default.
• W1982482362 creator A5068499035 @default.
• W1982482362 creator A5079933775 @default.
• W1982482362 date "2014-05-25" @default.
• W1982482362 modified "2023-10-03" @default.
• W1982482362 title "Rectal-Specific Microbicide Applicator: Evaluation and Comparison with a Vaginal Applicator Used Rectally" @default.
• W1982482362 cites W2022213850 @default.
• W1982482362 cites W2039665500 @default.
• W1982482362 cites W2044942586 @default.
• W1982482362 cites W2066519475 @default.
• W1982482362 cites W2066773902 @default.
• W1982482362 cites W2086580792 @default.
• W1982482362 cites W2088232987 @default.
• W1982482362 cites W2101319439 @default.
• W1982482362 cites W2115517188 @default.
• W1982482362 cites W2122769021 @default.
• W1982482362 cites W2142407602 @default.
• W1982482362 cites W2148056592 @default.
• W1982482362 cites W2162469267 @default.
• W1982482362 doi "https://doi.org/10.1007/s10461-014-0793-0" @default.
• W1982482362 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4320945" @default.
• W1982482362 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24858481" @default.
• W1982482362 hasPublicationYear "2014" @default.
• W1982482362 type Work @default.
• W1982482362 sameAs 1982482362 @default.
• W1982482362 citedByCount "18" @default.
• W1982482362 countsByYear W19824823622014 @default.
• W1982482362 countsByYear W19824823622015 @default.
• W1982482362 countsByYear W19824823622016 @default.
• W1982482362 countsByYear W19824823622017 @default.
• W1982482362 countsByYear W19824823622018 @default.
• W1982482362 countsByYear W19824823622021 @default.
• W1982482362 countsByYear W19824823622022 @default.
• W1982482362 crossrefType "journal-article" @default.
• W1982482362 hasAuthorship W1982482362A5009903397 @default.
• W1982482362 hasAuthorship W1982482362A5011885117 @default.
• W1982482362 hasAuthorship W1982482362A5012552931 @default.
• W1982482362 hasAuthorship W1982482362A5018723426 @default.
• W1982482362 hasAuthorship W1982482362A5025150770 @default.
• W1982482362 hasAuthorship W1982482362A5026208580 @default.
• W1982482362 hasAuthorship W1982482362A5030305126 @default.
• W1982482362 hasAuthorship W1982482362A5046912221 @default.
• W1982482362 hasAuthorship W1982482362A5054402928 @default.
• W1982482362 hasAuthorship W1982482362A5067046703 @default.
• W1982482362 hasAuthorship W1982482362A5068499035 @default.
• W1982482362 hasAuthorship W1982482362A5079933775 @default.
• W1982482362 hasBestOaLocation W19824823622 @default.
• W1982482362 hasConcept C105776082 @default.
• W1982482362 hasConcept C117214928 @default.
• W1982482362 hasConcept C138496976 @default.
• W1982482362 hasConcept C141071460 @default.
• W1982482362 hasConcept C142724271 @default.
• W1982482362 hasConcept C15744967 @default.
• W1982482362 hasConcept C197746943 @default.
• W1982482362 hasConcept C204787440 @default.
• W1982482362 hasConcept C27081682 @default.
• W1982482362 hasConcept C2776873419 @default.
• W1982482362 hasConcept C2776939746 @default.
• W1982482362 hasConcept C2776983459 @default.
• W1982482362 hasConcept C2777744392 @default.
• W1982482362 hasConcept C2908647359 @default.
• W1982482362 hasConcept C29456083 @default.
• W1982482362 hasConcept C2986740045 @default.
• W1982482362 hasConcept C2994333628 @default.
• W1982482362 hasConcept C3013748606 @default.
• W1982482362 hasConcept C42219234 @default.
• W1982482362 hasConcept C512399662 @default.
• W1982482362 hasConcept C71924100 @default.
• W1982482362 hasConcept C83674893 @default.
• W1982482362 hasConcept C99454951 @default.
• W1982482362 hasConceptScore W1982482362C105776082 @default.
• W1982482362 hasConceptScore W1982482362C117214928 @default.
• W1982482362 hasConceptScore W1982482362C138496976 @default.
• W1982482362 hasConceptScore W1982482362C141071460 @default.
• W1982482362 hasConceptScore W1982482362C142724271 @default.
• W1982482362 hasConceptScore W1982482362C15744967 @default.
• W1982482362 hasConceptScore W1982482362C197746943 @default.
• W1982482362 hasConceptScore W1982482362C204787440 @default.
• W1982482362 hasConceptScore W1982482362C27081682 @default.
• W1982482362 hasConceptScore W1982482362C2776873419 @default.
• W1982482362 hasConceptScore W1982482362C2776939746 @default.
• W1982482362 hasConceptScore W1982482362C2776983459 @default.
• W1982482362 hasConceptScore W1982482362C2777744392 @default.
• W1982482362 hasConceptScore W1982482362C2908647359 @default.
• W1982482362 hasConceptScore W1982482362C29456083 @default.
• W1982482362 hasConceptScore W1982482362C2986740045 @default.
• W1982482362 hasConceptScore W1982482362C2994333628 @default.

• next