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- W1982482371 abstract "Several clinical trials have failed to demonstrate a significant effect on outcome following human traumatic brain injury (TBI) despite promising results obtained in preclinical animal studies. These failures may be due in part to a misinterpretation of the findings obtained in preclinical animal models of TBI, a misunderstanding of the complexity of the human response to TBI, limited knowledge about the biological pathways that interact to contribute to good and bad outcomes after brain injury, and the effects of genomic variability and environment on individual recovery. Recent publications suggest that data obtained from gene expression profiling studies of complex neurological diseases such as stroke, multiple sclerosis (MS), Alzheimer’s and Parkinson’s may contribute to a more informed understanding of what affects outcome following TBI. These data may help to bridge the gap between successful preclinical studies and negative clinical trials in humans to reveal novel targets for therapy. Gene expression profiling has the capability to identify biomarkers associated with response to TBI, elucidate complex genetic interactions that may play a role in outcome following TBI, and reveal biological pathways related to brain health. This review highlights the current state of the literature on gene expression profiling for neurological disease and discusses its ability to aid in unraveling the variable human response to TBI and the potential for it to offer treatment strategies in an area where we currently have limited therapeutic options primarily based on supportive care." @default.
- W1982482371 created "2016-06-24" @default.
- W1982482371 creator A5015773529 @default.
- W1982482371 creator A5016803157 @default.
- W1982482371 creator A5075841448 @default.
- W1982482371 date "2010-11-26" @default.
- W1982482371 modified "2023-09-26" @default.
- W1982482371 title "Gene Expression Profiling for Discovery of Novel Targets in Human Traumatic Brain Injury" @default.
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- W1982482371 cites W1517096773 @default.
- W1982482371 cites W1544883203 @default.
- W1982482371 cites W1563833920 @default.
- W1982482371 cites W189298821 @default.
- W1982482371 cites W1965853922 @default.
- W1982482371 cites W1967399970 @default.
- W1982482371 cites W1968295744 @default.
- W1982482371 cites W1970156673 @default.
- W1982482371 cites W1972495948 @default.
- W1982482371 cites W1975034623 @default.
- W1982482371 cites W1977813572 @default.
- W1982482371 cites W1978195308 @default.
- W1982482371 cites W1984808901 @default.
- W1982482371 cites W1986720623 @default.
- W1982482371 cites W1992005009 @default.
- W1982482371 cites W1994761764 @default.
- W1982482371 cites W1994921312 @default.
- W1982482371 cites W1997375130 @default.
- W1982482371 cites W1998963293 @default.
- W1982482371 cites W1999369934 @default.
- W1982482371 cites W1999956368 @default.
- W1982482371 cites W2000334423 @default.
- W1982482371 cites W2006167447 @default.
- W1982482371 cites W2006485862 @default.
- W1982482371 cites W2009213539 @default.
- W1982482371 cites W2009475451 @default.
- W1982482371 cites W2010086107 @default.
- W1982482371 cites W2010637767 @default.
- W1982482371 cites W2011480812 @default.
- W1982482371 cites W2014218783 @default.
- W1982482371 cites W2014977509 @default.
- W1982482371 cites W2020983914 @default.
- W1982482371 cites W2023313786 @default.
- W1982482371 cites W2024610866 @default.
- W1982482371 cites W2025676338 @default.
- W1982482371 cites W2029441111 @default.
- W1982482371 cites W2030958510 @default.
- W1982482371 cites W2031205682 @default.
- W1982482371 cites W2032254195 @default.
- W1982482371 cites W2034150569 @default.
- W1982482371 cites W2039057614 @default.
- W1982482371 cites W2040950505 @default.
- W1982482371 cites W2042568428 @default.
- W1982482371 cites W2044061324 @default.
- W1982482371 cites W2044325685 @default.
- W1982482371 cites W2049373941 @default.
- W1982482371 cites W2050694917 @default.
- W1982482371 cites W2050800676 @default.
- W1982482371 cites W2064105382 @default.
- W1982482371 cites W2064580314 @default.
- W1982482371 cites W2064996657 @default.
- W1982482371 cites W2071114091 @default.
- W1982482371 cites W2077535738 @default.
- W1982482371 cites W2081341956 @default.
- W1982482371 cites W2081352868 @default.
- W1982482371 cites W2084979786 @default.
- W1982482371 cites W2086487393 @default.
- W1982482371 cites W2088191717 @default.
- W1982482371 cites W2088997949 @default.
- W1982482371 cites W2090348783 @default.
- W1982482371 cites W2092241603 @default.
- W1982482371 cites W2110112697 @default.
- W1982482371 cites W2115617081 @default.
- W1982482371 cites W2116146198 @default.
- W1982482371 cites W2118387485 @default.
- W1982482371 cites W2125961138 @default.
- W1982482371 cites W2129144238 @default.
- W1982482371 cites W2136059495 @default.
- W1982482371 cites W2136472588 @default.
- W1982482371 cites W2143858250 @default.
- W1982482371 cites W2151790869 @default.
- W1982482371 cites W2157503003 @default.
- W1982482371 cites W2160909535 @default.
- W1982482371 cites W2167483190 @default.
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- W1982482371 doi "https://doi.org/10.1177/1099800410385671" @default.
- W1982482371 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21112922" @default.
- W1982482371 hasPublicationYear "2010" @default.
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