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• W1982482411 abstract "Purpose. Previously we reported the occurrence of estrogen receptor a (ERa), estrogen receptor ß (ERß) and androgen receptor (AR) in mouse corneas. The present study was designed to investigate the occurrence of various sex steroid hormone receptors, including ERa, progesterone receptor (PR) and AR, in human corneas. Methods. We used reverse transcription-polymerase chain reaction (RT-PCR) to look for sex hormone receptor mRNAs (ERa, PR and AR) in human corneal epithelial cells obtained at autopsy. Next, using an immunocytochemical technique, we localized these receptors in donor human corneas. Results. mRNAs encoding all receptors tested for were found in corneal epithelial cells obtained from male and female donor eyes. Immunocytochemical examination revealed that the receptors were located in the nuclei of corneal epithelial, stromal, and endothelial cells. Conclusions. Since receptors for both male and female sex hormones are present in human corneas of both genders, we postulate that the receptors may influence the biological functions of corneal cells through direct interaction with specific hormones." @default.
• W1982482411 created "2016-06-24" @default.
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• W1982482411 date "2001-01-01" @default.
• W1982482411 modified "2023-10-09" @default.
• W1982482411 title "Expression of sex steroid hormone receptors in human cornea" @default.
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• W1982482411 doi "https://doi.org/10.1076/ceyr.22.1.28.6980" @default.
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