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- W1982483025 abstract "Elastic scattering or diffuse reflectance spectroscopy offers the possibility of distinguishing between cancerous and non- cancerous tissue in the breast with a relatively simple optical measurement. The measurement of the relative reflection of light has previously been shown to be sensitive to both the size and distribution of intra and inter-cellular structures as well as absorption from chromophores, which are present in the tissue. Coupling a white light source and spectrometer to optic fibers makes it possible to construct probes that can be inserted percutaneously or used intra- operatively to take in-vivo spectra from breast tissue or ex- vivo spectra from excised sentinel nodes. This 'optical biopsy' is correlated with a conventional histopathological specimen obtained at the same point. Spectra are reported from a large number of patients with benign and malignant lesions. Some of the differences that appear in these spectra are outlined and the uses and limitations of this technique for in-vivo diagnosis are discussed. It is shown that to a relatively high degree of sensitivity and specificity it is possible to distinguish between malignant tumors, benign lesions and normal tissue." @default.
- W1982483025 created "2016-06-24" @default.
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- W1982483025 date "2000-05-17" @default.
- W1982483025 modified "2023-09-23" @default.
- W1982483025 title "Optical biopsy: in-vivo diagnosis of breast cancer using elastic scatter spectroscopy" @default.
- W1982483025 doi "https://doi.org/10.1117/12.386304" @default.
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