FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982483898> ?p ?o ?g. }

• W1982483898 endingPage "549" @default.
• W1982483898 startingPage "542" @default.
• W1982483898 abstract "ALK-5 (Activin-Like Kinase 5) is a biological receptor involved in a variety of pathological processes such as cancer and fibrosis. ALK-5 receptor propagates an intracellular signaling that forms a protein complex capable of reaching the nucleus and modulating the gene transcription. In the present study, comparative molecular field analysis (CoMFA) and hologram quantitative structure–activity relationship (HQSAR) studies were conducted on a series of potent ALK-5 inhibitors. Significant correlation coefficients (CoMFA, r2 = 0.99 and q2 = 0.85; HQSAR, r2 = 0.92 and q2 = 0.72) were obtained, indicating the predictive potential of the 2D and 3D models for untested compounds. The models were then used to predict the potency of a test set, and the predicted values from the HQSAR and CoMFA models were in good agreement with the experimental results. The final QSAR models, along with the information obtained from 3D (steric and electrostatic) contour maps and 2D contribution maps, can be useful for the design of novel bioactive ligands." @default.
• W1982483898 created "2016-06-24" @default.
• W1982483898 creator A5001719421 @default.
• W1982483898 creator A5034015138 @default.
• W1982483898 creator A5044360721 @default.
• W1982483898 date "2013-07-01" @default.
• W1982483898 modified "2023-10-18" @default.
• W1982483898 title "Computational studies of TGF-βRI (ALK-5) inhibitors: Analysis of the binding interactions between ligand–receptor using 2D and 3D techniques" @default.
• W1982483898 cites W1963767618 @default.
• W1982483898 cites W1966821093 @default.
• W1982483898 cites W1986373964 @default.
• W1982483898 cites W1987449859 @default.
• W1982483898 cites W1992468405 @default.
• W1982483898 cites W1992637219 @default.
• W1982483898 cites W1998518612 @default.
• W1982483898 cites W2009308766 @default.
• W1982483898 cites W2012563646 @default.
• W1982483898 cites W2033983313 @default.
• W1982483898 cites W2036300374 @default.
• W1982483898 cites W2037926034 @default.
• W1982483898 cites W2038455596 @default.
• W1982483898 cites W2039851904 @default.
• W1982483898 cites W2046547485 @default.
• W1982483898 cites W2050986127 @default.
• W1982483898 cites W2061922454 @default.
• W1982483898 cites W2061958868 @default.
• W1982483898 cites W2063060349 @default.
• W1982483898 cites W2064353395 @default.
• W1982483898 cites W2067290645 @default.
• W1982483898 cites W2069107763 @default.
• W1982483898 cites W2070291200 @default.
• W1982483898 cites W2077569843 @default.
• W1982483898 cites W2077776336 @default.
• W1982483898 cites W2082364443 @default.
• W1982483898 cites W2087661061 @default.
• W1982483898 cites W2088272294 @default.
• W1982483898 cites W2088393212 @default.
• W1982483898 cites W2100349128 @default.
• W1982483898 cites W2103720408 @default.
• W1982483898 cites W2105182686 @default.
• W1982483898 cites W2110767133 @default.
• W1982483898 cites W2126605161 @default.
• W1982483898 cites W2127336290 @default.
• W1982483898 cites W2132629607 @default.
• W1982483898 cites W2133528707 @default.
• W1982483898 cites W2134450203 @default.
• W1982483898 cites W2138302880 @default.
• W1982483898 cites W2150572803 @default.
• W1982483898 cites W2155358697 @default.
• W1982483898 cites W2159799774 @default.
• W1982483898 cites W2162981115 @default.
• W1982483898 cites W2163797065 @default.
• W1982483898 cites W2164088236 @default.
• W1982483898 cites W2999197824 @default.
• W1982483898 doi "https://doi.org/10.1016/j.ejps.2013.05.015" @default.
• W1982483898 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23727056" @default.
• W1982483898 hasPublicationYear "2013" @default.
• W1982483898 type Work @default.
• W1982483898 sameAs 1982483898 @default.
• W1982483898 citedByCount "18" @default.
• W1982483898 countsByYear W19824838982014 @default.
• W1982483898 countsByYear W19824838982015 @default.
• W1982483898 countsByYear W19824838982016 @default.
• W1982483898 countsByYear W19824838982017 @default.
• W1982483898 countsByYear W19824838982018 @default.
• W1982483898 countsByYear W19824838982019 @default.
• W1982483898 countsByYear W19824838982020 @default.
• W1982483898 countsByYear W19824838982021 @default.
• W1982483898 countsByYear W19824838982022 @default.
• W1982483898 crossrefType "journal-article" @default.
• W1982483898 hasAuthorship W1982483898A5001719421 @default.
• W1982483898 hasAuthorship W1982483898A5034015138 @default.
• W1982483898 hasAuthorship W1982483898A5044360721 @default.
• W1982483898 hasConcept C116569031 @default.
• W1982483898 hasConcept C164126121 @default.
• W1982483898 hasConcept C170493617 @default.
• W1982483898 hasConcept C178910836 @default.
• W1982483898 hasConcept C185592680 @default.
• W1982483898 hasConcept C201194858 @default.
• W1982483898 hasConcept C202751555 @default.
• W1982483898 hasConcept C55493867 @default.
• W1982483898 hasConcept C57992300 @default.
• W1982483898 hasConcept C70721500 @default.
• W1982483898 hasConcept C71240020 @default.
• W1982483898 hasConcept C86803240 @default.
• W1982483898 hasConceptScore W1982483898C116569031 @default.
• W1982483898 hasConceptScore W1982483898C164126121 @default.
• W1982483898 hasConceptScore W1982483898C170493617 @default.
• W1982483898 hasConceptScore W1982483898C178910836 @default.
• W1982483898 hasConceptScore W1982483898C185592680 @default.
• W1982483898 hasConceptScore W1982483898C201194858 @default.
• W1982483898 hasConceptScore W1982483898C202751555 @default.
• W1982483898 hasConceptScore W1982483898C55493867 @default.
• W1982483898 hasConceptScore W1982483898C57992300 @default.
• W1982483898 hasConceptScore W1982483898C70721500 @default.
• W1982483898 hasConceptScore W1982483898C71240020 @default.
• W1982483898 hasConceptScore W1982483898C86803240 @default.
• W1982483898 hasIssue "4" @default.

• next