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- W1982485797 abstract "Overproduction of Amyloid Precursor Protein (APP) and beta-amyloid likely contribute to neurodegeneration seen in Alzheimer's Disease (AD). Elevated APP mRNA levels are positively correlated with downstream beta-amyloid production both in AD and Down's Syndrome. APP mRNA contains several cis-acting regulatory elements, one of which (52sce) has been recently shown to complex with uncharacterized cytoplasmic proteins. 52sce-binding proteins were isolated by affinity purification with 52sce oligoribonucleotide, and identified through trypsin digestion and mass spectroscopy. APP mRNA was detected in immunoprecipitates of 52sce-binding proteins from human neuroblasts through real-time PCR. Rck/p54, one of the identified proteins, was overexpressed in human neuroblasts by Rck gene transfection or TAT-fusion protein transduction. APP mRNA and protein levels in treated and control cells were assayed with real-time PCR and immunocytochemistry, respectively. We identify six novel proteins that specifically bind to 52sce and interact with APP mRNA in intact human neuroblastoma cells. Overexpression of one of these proteins, rck/p54, upregulated APP mRNA and protein in those cells. These data suggest a novel mechanism for post-transcriptional regulation of APP mRNA." @default.
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- W1982485797 date "2008-07-01" @default.
- W1982485797 modified "2023-09-27" @default.
- W1982485797 title "P1-462: Rck/p54 upregulates amyloid precursor protein messenger RNA as part of a novel RNA-binding protein complex" @default.
- W1982485797 doi "https://doi.org/10.1016/j.jalz.2008.05.1045" @default.
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