Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982486473> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W1982486473 abstract "Adult rat cardiac endothelin-1 (ET-1) receptors were solubilized with 0.5% digitonin and then characterized. The receptors retained binding activity after solubilization. Binding was saturable (KD of 0.065 +/- 0.004 nM, Bmax of 94.6 +/- 4.5 fmol/mg protein; Hill coefficient of 0.987 +/- 0.017 n = 6) and pH dependent, with the binding increasing as the pH was decreased from 10 to 4, but decreasing dramatically as pH dropped to 2. Specifically bound [125I]-ET-1 was not dissociated by 2 x 10(-7) M unlabelled ET-1, but was dissociated by pH 10 and 2. Returning the pH to 7.4 restored the binding activity of the receptors. Unlabelled ET-1 (10(-12) - 10(-7) M) and sarafotoxin S6b(10(-12) - 10(-7) M) competed with [125I]-ET-1 for binding to the receptors." @default.
- W1982486473 created "2016-06-24" @default.
- W1982486473 creator A5011257003 @default.
- W1982486473 creator A5038217374 @default.
- W1982486473 creator A5041080369 @default.
- W1982486473 creator A5044990471 @default.
- W1982486473 creator A5073453429 @default.
- W1982486473 date "1990-01-01" @default.
- W1982486473 modified "2023-09-24" @default.
- W1982486473 title "Solubilization and characterization of endothelin-1 receptors in rat cardiac tissue" @default.
- W1982486473 cites W1775749144 @default.
- W1982486473 cites W1963709456 @default.
- W1982486473 cites W1965289299 @default.
- W1982486473 cites W1978001779 @default.
- W1982486473 cites W1979174681 @default.
- W1982486473 cites W2052165825 @default.
- W1982486473 cites W2065510140 @default.
- W1982486473 cites W2091277681 @default.
- W1982486473 cites W2162804111 @default.
- W1982486473 doi "https://doi.org/10.1016/0006-291x(90)91945-o" @default.
- W1982486473 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2154201" @default.
- W1982486473 hasPublicationYear "1990" @default.
- W1982486473 type Work @default.
- W1982486473 sameAs 1982486473 @default.
- W1982486473 citedByCount "12" @default.
- W1982486473 crossrefType "journal-article" @default.
- W1982486473 hasAuthorship W1982486473A5011257003 @default.
- W1982486473 hasAuthorship W1982486473A5038217374 @default.
- W1982486473 hasAuthorship W1982486473A5041080369 @default.
- W1982486473 hasAuthorship W1982486473A5044990471 @default.
- W1982486473 hasAuthorship W1982486473A5073453429 @default.
- W1982486473 hasConcept C107824862 @default.
- W1982486473 hasConcept C12554922 @default.
- W1982486473 hasConcept C144980905 @default.
- W1982486473 hasConcept C170493617 @default.
- W1982486473 hasConcept C181199279 @default.
- W1982486473 hasConcept C185592680 @default.
- W1982486473 hasConcept C2778920010 @default.
- W1982486473 hasConcept C4863142 @default.
- W1982486473 hasConcept C55493867 @default.
- W1982486473 hasConcept C86803240 @default.
- W1982486473 hasConceptScore W1982486473C107824862 @default.
- W1982486473 hasConceptScore W1982486473C12554922 @default.
- W1982486473 hasConceptScore W1982486473C144980905 @default.
- W1982486473 hasConceptScore W1982486473C170493617 @default.
- W1982486473 hasConceptScore W1982486473C181199279 @default.
- W1982486473 hasConceptScore W1982486473C185592680 @default.
- W1982486473 hasConceptScore W1982486473C2778920010 @default.
- W1982486473 hasConceptScore W1982486473C4863142 @default.
- W1982486473 hasConceptScore W1982486473C55493867 @default.
- W1982486473 hasConceptScore W1982486473C86803240 @default.
- W1982486473 hasLocation W19824864731 @default.
- W1982486473 hasLocation W19824864732 @default.
- W1982486473 hasOpenAccess W1982486473 @default.
- W1982486473 hasPrimaryLocation W19824864731 @default.
- W1982486473 hasRelatedWork W1982486473 @default.
- W1982486473 hasRelatedWork W2006564159 @default.
- W1982486473 hasRelatedWork W2032291527 @default.
- W1982486473 hasRelatedWork W2039761283 @default.
- W1982486473 hasRelatedWork W2218409228 @default.
- W1982486473 hasRelatedWork W2327730408 @default.
- W1982486473 hasRelatedWork W2333159847 @default.
- W1982486473 hasRelatedWork W2352115104 @default.
- W1982486473 hasRelatedWork W2405892738 @default.
- W1982486473 hasRelatedWork W2622219096 @default.
- W1982486473 isParatext "false" @default.
- W1982486473 isRetracted "false" @default.
- W1982486473 magId "1982486473" @default.
- W1982486473 workType "article" @default.