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- W1982489572 abstract "In B-cell development, expression of immunoglobulin heavy-chain variable-region (VH) gene repertoires is determined by genetic mechanisms that favor rearrangement of the most D-proximal genes, resulting in overutilization of the VH7183 gene family early in ontogeny and in differentiating B cells of the adult bone marrow. Maturation of the immune system is accompanied by a decreased expression of VH7183 genes in the peripheral immunocompetent B-cell pool of adult animals. By comparing VH gene family expression in the bone marrow (emergent) and peripheral (available and actual) B-cell repertoires of germ-free and conventionally raised BALB/c mice, we found that peripheral selection of VH gene family utilization does not occur in germ-free animals. Reconstitution of germ-free mice with normal serum immunoglobulins purified from syngeneic donors reestablishes selection of VH7183-expressing B cells. Our results indicate that preimmune B-cell repertoires are selected in normal animals by environmental antigens and serum immunoglobulins." @default.
- W1982489572 created "2016-06-24" @default.
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- W1982489572 date "1991-07-01" @default.
- W1982489572 modified "2023-10-14" @default.
- W1982489572 title "Normal serum immunoglobulins participate in the selection of peripheral B-cell repertoires." @default.
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- W1982489572 doi "https://doi.org/10.1073/pnas.88.13.5640" @default.
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