Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982489954> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W1982489954 endingPage "704" @default.
- W1982489954 startingPage "699" @default.
- W1982489954 abstract "Superoxide and hydroxyl free radicals are strongly implicated in the deleterious effects of reperfusion of grafted organs. Iron ions are critical in the Fenton-like reaction that generates oxygen-free radicals from H2O2. Using the ADP/Fe2+/H2O2 .OH-generating system, we demonstrated that components of an organ-preservation solution (Henri Mondor solution): sodium lactobionate, adenine, and a nitroxide radical: 4-hydroxy-2,2,6,6-tetramethylpiperidine-n-oxyl (TEMPOL), showed unexpected inhibition properties on the production of hydroxyl radicals by complexation of Fe2+ for lactobionate and nitroxide or Fe3+ for adenine. This inhibition was 75.5% at 12 mM lactobionate. Moreover, a complete inhibition was observed at 50 mM. At 0.25 mM adenine, the reduction was 14.8% (maximum effect: 34.1%). Henri Mondor solution, at an identical adenine and lactobionate concentration, inhibited the radical production by 91.5%, indicating an additive effect. Nitroxide totally inhibited .OH production by the ADP/Fe2+/H2O2 system (maximum effect: 95.6%) and partially the production by an O2.- generating system (maximum effect: 74.8%). Thus, the association of these three components in preservation solutions would be an original method to limit the reperfusion injury observed in isolated ischemic organs." @default.
- W1982489954 created "2016-06-24" @default.
- W1982489954 creator A5007131845 @default.
- W1982489954 creator A5048664489 @default.
- W1982489954 creator A5055014867 @default.
- W1982489954 creator A5091846578 @default.
- W1982489954 date "1995-11-01" @default.
- W1982489954 modified "2023-09-25" @default.
- W1982489954 title "Inhibition of hydroxyl radical production by lactobionate, adenine, and tempol" @default.
- W1982489954 cites W1038327558 @default.
- W1982489954 cites W1164770037 @default.
- W1982489954 cites W1423878457 @default.
- W1982489954 cites W1493537648 @default.
- W1982489954 cites W1590116013 @default.
- W1982489954 cites W1630602822 @default.
- W1982489954 cites W1734082729 @default.
- W1982489954 cites W1973366975 @default.
- W1982489954 cites W1992006082 @default.
- W1982489954 cites W1999220416 @default.
- W1982489954 cites W2006462275 @default.
- W1982489954 cites W2024092039 @default.
- W1982489954 cites W2035228551 @default.
- W1982489954 cites W2042582442 @default.
- W1982489954 cites W2053145973 @default.
- W1982489954 cites W2066497363 @default.
- W1982489954 cites W2073119484 @default.
- W1982489954 cites W2078523639 @default.
- W1982489954 cites W2104145747 @default.
- W1982489954 cites W2409447834 @default.
- W1982489954 cites W2416837340 @default.
- W1982489954 cites W301492158 @default.
- W1982489954 doi "https://doi.org/10.1016/0891-5849(95)00079-d" @default.
- W1982489954 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8529932" @default.
- W1982489954 hasPublicationYear "1995" @default.
- W1982489954 type Work @default.
- W1982489954 sameAs 1982489954 @default.
- W1982489954 citedByCount "45" @default.
- W1982489954 countsByYear W19824899542012 @default.
- W1982489954 countsByYear W19824899542013 @default.
- W1982489954 countsByYear W19824899542015 @default.
- W1982489954 countsByYear W19824899542016 @default.
- W1982489954 countsByYear W19824899542017 @default.
- W1982489954 countsByYear W19824899542018 @default.
- W1982489954 countsByYear W19824899542019 @default.
- W1982489954 countsByYear W19824899542021 @default.
- W1982489954 countsByYear W19824899542022 @default.
- W1982489954 crossrefType "journal-article" @default.
- W1982489954 hasAuthorship W1982489954A5007131845 @default.
- W1982489954 hasAuthorship W1982489954A5048664489 @default.
- W1982489954 hasAuthorship W1982489954A5055014867 @default.
- W1982489954 hasAuthorship W1982489954A5091846578 @default.
- W1982489954 hasConcept C111998727 @default.
- W1982489954 hasConcept C139066938 @default.
- W1982489954 hasConcept C13965031 @default.
- W1982489954 hasConcept C169912494 @default.
- W1982489954 hasConcept C178790620 @default.
- W1982489954 hasConcept C181199279 @default.
- W1982489954 hasConcept C185592680 @default.
- W1982489954 hasConcept C2776778087 @default.
- W1982489954 hasConcept C2780795997 @default.
- W1982489954 hasConcept C44228677 @default.
- W1982489954 hasConcept C521977710 @default.
- W1982489954 hasConcept C540031477 @default.
- W1982489954 hasConcept C55493867 @default.
- W1982489954 hasConceptScore W1982489954C111998727 @default.
- W1982489954 hasConceptScore W1982489954C139066938 @default.
- W1982489954 hasConceptScore W1982489954C13965031 @default.
- W1982489954 hasConceptScore W1982489954C169912494 @default.
- W1982489954 hasConceptScore W1982489954C178790620 @default.
- W1982489954 hasConceptScore W1982489954C181199279 @default.
- W1982489954 hasConceptScore W1982489954C185592680 @default.
- W1982489954 hasConceptScore W1982489954C2776778087 @default.
- W1982489954 hasConceptScore W1982489954C2780795997 @default.
- W1982489954 hasConceptScore W1982489954C44228677 @default.
- W1982489954 hasConceptScore W1982489954C521977710 @default.
- W1982489954 hasConceptScore W1982489954C540031477 @default.
- W1982489954 hasConceptScore W1982489954C55493867 @default.
- W1982489954 hasIssue "5" @default.
- W1982489954 hasLocation W19824899541 @default.
- W1982489954 hasLocation W19824899542 @default.
- W1982489954 hasOpenAccess W1982489954 @default.
- W1982489954 hasPrimaryLocation W19824899541 @default.
- W1982489954 hasRelatedWork W161717848 @default.
- W1982489954 hasRelatedWork W1994067736 @default.
- W1982489954 hasRelatedWork W1995343884 @default.
- W1982489954 hasRelatedWork W2005924227 @default.
- W1982489954 hasRelatedWork W2016184447 @default.
- W1982489954 hasRelatedWork W2081063731 @default.
- W1982489954 hasRelatedWork W2350408869 @default.
- W1982489954 hasRelatedWork W2372245020 @default.
- W1982489954 hasRelatedWork W2373500013 @default.
- W1982489954 hasRelatedWork W895038953 @default.
- W1982489954 hasVolume "19" @default.
- W1982489954 isParatext "false" @default.
- W1982489954 isRetracted "false" @default.
- W1982489954 magId "1982489954" @default.
- W1982489954 workType "article" @default.