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• W1982494911 abstract "A series of new ceritinib analogs by extensive functionalization of the tail piperidine ring with various phosphamides and carbamates have been synthesized. All the ceritinib derivatives were evaluated for their cytotoxic activities against H2228 cell line. From the activity profile obtained, three of the tested compounds (compounds 4, 7 and 9) showed significant cytotoxic effects. Among these derivatives compound 9 was found to possess cytotoxicity that is better than standard drug ceritinib (IC50 = 24 nM). Moreover, compound 9 demonstrated robust tumor growth inhibition in vivo model." @default.
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• W1982494911 date "2015-03-01" @default.
• W1982494911 modified "2023-10-18" @default.
• W1982494911 title "Synthesis and anticancer activities of ceritinib analogs modified in the terminal piperidine ring" @default.
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• W1982494911 doi "https://doi.org/10.1016/j.ejmech.2015.01.056" @default.
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