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- W1982507112 abstract "1 The aim of the study was to examine the potential pharmacokinetic interaction between methotrexate and flucloxacillin. 2 Ten rheumatoid arthritis patients participated in the interaction study. Subjects were allocated to either methotrexate alone (5–15 mg per week) or methotrexate plus flucloxacillin (500 mg four times a day 48 h prior to sampling) in a random order. 3 There was a statistically, but not clinically, significant decrease in methotrexate AUC (1307 ± 389 vs 1212 ± 394 μg 1--1 h) in the presence of flucloxacillin. Cmax and tmax parameters for methotrexate were not significantly altered in the presence of flucloxacillin. 4 Data from an additional 10 rheumatoid arthritis patients, starting on methotrexate, were added to the data from the placebo arm of the interaction study and a model dependent pharmacokinetic analysis was performed. The plasma concentration profiles were best described by a two-compartment model with a mean clearance of 11.9 (± 1.7) 1 h-1 and an initial volume of distribution of 31.2 (± 2.6) 1. The pronounced intersubject variability in the pharmacokinetic parameters was not related to any of the available covariate information. 5 Our findings suggest that no important clinical interaction occurs between flucloxacillin and methotrexate in patients with rheumatoid arthritis." @default.
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- W1982507112 date "1996-03-01" @default.
- W1982507112 modified "2023-09-27" @default.
- W1982507112 title "Lack of interaction between flucloxacillin and methotrexate in pa tien t s with rheumatoid arthritis" @default.
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- W1982507112 doi "https://doi.org/10.1111/j.1365-2125.1996.tb00186.x" @default.
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