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• W1982529683 startingPage "1097" @default.
• W1982529683 abstract "The role of B cells as APC is well established. However, their ability to prime naive T cells in vivo has been difficult to examine because of the presence of dendritic cells. The current studies were undertaken to examine this issue in a model of adoptive transfer of antigen-specific B cells and T cells into histoincompatible Rag2–/– mice. By means of this system, we were able to demonstrate that antigen-specific B cells are competent APC for naive CD4+ T cells specific for the same antigen. In vivo antigen presentation resulted in expansion of both CD4+ T cells and B cells. The antigen-presenting function of the transferred B cells was dependent on the CD154-CD40 interaction, as transfer of CD154-deficient antigen-specific CD4+ T cells or CD40-deficient B cells failed to induce T and B cell expansion in response to immunization. These results indicate that antigen-specific B cells have the capacity to induce primary T cell responses in the absence of other competent APC." @default.
• W1982529683 created "2016-06-24" @default.
• W1982529683 creator A5005320356 @default.
• W1982529683 creator A5034403857 @default.
• W1982529683 date "2005-03-09" @default.
• W1982529683 modified "2023-09-23" @default.
• W1982529683 title "B cells can prime naive CD4⁺T cells<i>in vivo</i>in the absence of other professional antigen-presenting cells in a CD154-CD40-dependent manner" @default.
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• W1982529683 doi "https://doi.org/10.1002/eji.200425732" @default.
• W1982529683 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15756646" @default.
• W1982529683 hasPublicationYear "2005" @default.
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