Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982531644> ?p ?o ?g. }
- W1982531644 endingPage "558" @default.
- W1982531644 startingPage "552" @default.
- W1982531644 abstract "Objectives Cerebral edema is a major cause of death during acute liver failure (ALF), but the exact mechanism of this condition is still not entirely clear. The aim of this study was to investigate the role of tumor necrosis factor α (TNFα) in changing the permeability of the blood–brain barrier (BBB) during acetaminophen (APAP)-induced ALF. Materials and methods ALF animal models were generated by administering APAP. Anti-TNFα-IgG was intravenously injected (100 μg/mouse) 2 h after administration of APAP. We investigated BBB permeability with Evans blue staining, and structure with electron microscopy. Results BBB permeability increased in APAP-induced ALF mice and correlated with elevated serum TNFα levels. Electron microscopy of mouse brain tissues revealed tight junction (TJ) disruptions and endothelial cell shrinkage, as well as increased vesicles and vacuoles. In addition, the expression of the TJ-associated protein, occludin, was significantly decreased in APAP-induced ALF mice. Changes in BBB permeability and occludin expression could be prevented by administering anti-TNFα-IgG 2 h after APAP challenge. Conclusion TNFα plays a critical role in the development of brain edema in APAP-induced ALF. Increased BBB permeability may be due to the loss of the TJ-associated protein occludin." @default.
- W1982531644 created "2016-06-24" @default.
- W1982531644 creator A5004939305 @default.
- W1982531644 creator A5036148802 @default.
- W1982531644 creator A5041438685 @default.
- W1982531644 creator A5049242358 @default.
- W1982531644 creator A5052655094 @default.
- W1982531644 creator A5063132036 @default.
- W1982531644 date "2011-07-01" @default.
- W1982531644 modified "2023-09-26" @default.
- W1982531644 title "Tumor necrosis factor-α affects blood–brain barrier permeability in acetaminophen-induced acute liver failure" @default.
- W1982531644 cites W1515404010 @default.
- W1982531644 cites W1605333679 @default.
- W1982531644 cites W1715236271 @default.
- W1982531644 cites W1967684747 @default.
- W1982531644 cites W1969248415 @default.
- W1982531644 cites W1991966831 @default.
- W1982531644 cites W1998078168 @default.
- W1982531644 cites W2004365491 @default.
- W1982531644 cites W2008264563 @default.
- W1982531644 cites W2010213397 @default.
- W1982531644 cites W2011583083 @default.
- W1982531644 cites W2016753320 @default.
- W1982531644 cites W2034692102 @default.
- W1982531644 cites W2040022930 @default.
- W1982531644 cites W2040100166 @default.
- W1982531644 cites W2042909706 @default.
- W1982531644 cites W2048154576 @default.
- W1982531644 cites W2048656662 @default.
- W1982531644 cites W2053963421 @default.
- W1982531644 cites W2059044221 @default.
- W1982531644 cites W2066134367 @default.
- W1982531644 cites W2078276534 @default.
- W1982531644 cites W2079482620 @default.
- W1982531644 cites W2084123893 @default.
- W1982531644 cites W2085146964 @default.
- W1982531644 cites W2089424886 @default.
- W1982531644 cites W2090546037 @default.
- W1982531644 cites W2100516941 @default.
- W1982531644 cites W2100835385 @default.
- W1982531644 cites W2102090879 @default.
- W1982531644 cites W2103831817 @default.
- W1982531644 cites W2111100642 @default.
- W1982531644 cites W2118525371 @default.
- W1982531644 cites W2132674187 @default.
- W1982531644 cites W2155957079 @default.
- W1982531644 cites W2159873016 @default.
- W1982531644 cites W2160771998 @default.
- W1982531644 cites W2163790438 @default.
- W1982531644 cites W2164672978 @default.
- W1982531644 cites W310193716 @default.
- W1982531644 doi "https://doi.org/10.1097/meg.0b013e3283470212" @default.
- W1982531644 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21593677" @default.
- W1982531644 hasPublicationYear "2011" @default.
- W1982531644 type Work @default.
- W1982531644 sameAs 1982531644 @default.
- W1982531644 citedByCount "27" @default.
- W1982531644 countsByYear W19825316442012 @default.
- W1982531644 countsByYear W19825316442013 @default.
- W1982531644 countsByYear W19825316442015 @default.
- W1982531644 countsByYear W19825316442016 @default.
- W1982531644 countsByYear W19825316442017 @default.
- W1982531644 countsByYear W19825316442018 @default.
- W1982531644 countsByYear W19825316442019 @default.
- W1982531644 countsByYear W19825316442020 @default.
- W1982531644 countsByYear W19825316442021 @default.
- W1982531644 countsByYear W19825316442022 @default.
- W1982531644 countsByYear W19825316442023 @default.
- W1982531644 crossrefType "journal-article" @default.
- W1982531644 hasAuthorship W1982531644A5004939305 @default.
- W1982531644 hasAuthorship W1982531644A5036148802 @default.
- W1982531644 hasAuthorship W1982531644A5041438685 @default.
- W1982531644 hasAuthorship W1982531644A5049242358 @default.
- W1982531644 hasAuthorship W1982531644A5052655094 @default.
- W1982531644 hasAuthorship W1982531644A5063132036 @default.
- W1982531644 hasConcept C113045295 @default.
- W1982531644 hasConcept C126322002 @default.
- W1982531644 hasConcept C134018914 @default.
- W1982531644 hasConcept C177779419 @default.
- W1982531644 hasConcept C17991360 @default.
- W1982531644 hasConcept C185592680 @default.
- W1982531644 hasConcept C2775962179 @default.
- W1982531644 hasConcept C2777649898 @default.
- W1982531644 hasConcept C2778402981 @default.
- W1982531644 hasConcept C2778722691 @default.
- W1982531644 hasConcept C529278444 @default.
- W1982531644 hasConcept C55493867 @default.
- W1982531644 hasConcept C71924100 @default.
- W1982531644 hasConcept C98274493 @default.
- W1982531644 hasConceptScore W1982531644C113045295 @default.
- W1982531644 hasConceptScore W1982531644C126322002 @default.
- W1982531644 hasConceptScore W1982531644C134018914 @default.
- W1982531644 hasConceptScore W1982531644C177779419 @default.
- W1982531644 hasConceptScore W1982531644C17991360 @default.
- W1982531644 hasConceptScore W1982531644C185592680 @default.
- W1982531644 hasConceptScore W1982531644C2775962179 @default.
- W1982531644 hasConceptScore W1982531644C2777649898 @default.
- W1982531644 hasConceptScore W1982531644C2778402981 @default.