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• W1982551617 endingPage "505104" @default.
• W1982551617 startingPage "505104" @default.
• W1982551617 abstract "A novel multifunctional magnetic nanocarrier was fabricated for synchronous cancer therapy and sensing. The nanocarrier, programed to display a response to environmental stimuli (pH value), was synthesized by coupling doxorubicin (DOX) to adipic dihydrazide-grafted gum arabic modified magnetic nanoparticles (ADH-GAMNP) via the hydrolytically degradable pH-sensitive hydrazone bond. The resultant nanocarrier, DOX-ADH-GAMNP, had a mean diameter of 13.8 nm and the amount of DOX coupled was about 6.52 mg g(-1). Also, it exhibited pH triggered release of DOX in an acidic environment (pH 5.0) but was relatively stable at physiological pH (pH 7.4). Furthermore, both GAMNP and DOX were found to possess fluorescence properties when excited in the near-infrared region due to the two-photon absorption mechanism. The coupling of DOX to GAMNP resulted in a reversible self-quenching of fluorescence through the fluorescence resonant energy transfer (FRET) between the donor GAMNP and acceptor DOX. The release of DOX from DOX-ADH-GAMNP when exposed to acidic media indicated the recovery of fluorescence from both GAMNP and DOX. The change in the fluorescence intensity of DOX-ADH-GAMNP on the release of DOX can act as a potential sensor to sense the delivery of the drug. The analysis of zeta potential and plasmon absorbance in different pH conditions also confirmed the pH sensitivity of the product. This multifunctional nanocarrier is a significant breakthrough in developing a drug delivery vehicle that combines drug targeting as well as sensing and therapy at the same time." @default.
• W1982551617 created "2016-06-24" @default.
• W1982551617 creator A5002048437 @default.
• W1982551617 creator A5091089792 @default.
• W1982551617 date "2008-11-24" @default.
• W1982551617 modified "2023-09-25" @default.
• W1982551617 title "Multifunctional pH-sensitive magnetic nanoparticles for simultaneous imaging, sensing and targeted intracellular anticancer drug delivery" @default.
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• W1982551617 doi "https://doi.org/10.1088/0957-4484/19/50/505104" @default.
• W1982551617 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19942761" @default.
• W1982551617 hasPublicationYear "2008" @default.
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