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• W1982579673 abstract "The canonical Wnt signaling pathway can determine human bone marrow stromal (mesenchymal) stem cell (hMSC) differentiation fate into osteoblast or adipocyte lineages. However, its downstream targets in MSC are not well characterized. Thus, using DNA microarrays, we compared global gene expression patterns induced by Wnt3a treatment in two hMSC lines: hMSC-LRP5(T253) and hMSC-LRP5(T244) cells carrying known mutations of Wnt co-receptor LRP5 (T253I or T244M) that either enhances or represses canonical Wnt signaling, respectively. Wnt3a treatment of hMSC activated not only canonical Wnt signaling, but also the non-canonical Wnt/JNK pathway through upregulation of several non-canonical Wnt components e.g. naked cuticle 1 homolog (NKD1) and WNT11. Activation of the non-canonical Wnt/JNK pathway by anisomycin enhanced osteoblast differentiation whereas its inhibition by SP600125 enhanced adipocyte differentiation of hMSC. In conclusion, canonical and non-canonical Wnt signaling cooperate in determining MSC differentiation fate." @default.
• W1982579673 created "2016-06-24" @default.
• W1982579673 creator A5035262769 @default.
• W1982579673 creator A5055678790 @default.
• W1982579673 creator A5078942892 @default.
• W1982579673 date "2011-09-01" @default.
• W1982579673 modified "2023-10-11" @default.
• W1982579673 title "Activation of non-canonical Wnt/JNK pathway by Wnt3a is associated with differentiation fate determination of human bone marrow stromal (mesenchymal) stem cells" @default.
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• W1982579673 doi "https://doi.org/10.1016/j.bbrc.2011.08.061" @default.
• W1982579673 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21875572" @default.
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