FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982596539> ?p ?o ?g. }

• W1982596539 endingPage "30" @default.
• W1982596539 startingPage "23" @default.
• W1982596539 abstract "Although in vitro anchorage-independent growth is widely used as a marker of cell transformation, the biological implications of this trait are poorly understood. We previously demonstrated that enforced anchorage-independent growth of a nontumorigenic, immortalized epithelial cell line (IEC-18) in multicellular spheroid culture results in massive apoptotic cell death. This death process, termed anoikis, is prevented by expression of transforming oncogenes, which also confer tumorigenic competence. This study examines whether acquisition of an anoikis-resistant phenotype is causally related to the tumorigenic capacity of transformed epithelial cells. Parental IEC-18 cells were subjected to 10 cycles of selection for survival in speroid culture. Unlike parental cells, the resulting anoikis-resistant variants (AR1.10 and AR2.10) formed relatively large tumors in nude mice. Both anoikis-resistant sublines displayed upregulated expression of vascular endothelial growth factor (VEGF), a potent angiogenesis stimulator. VEGF121 overexpression alone did not induce tumorigenic conversion of parental IEC-18 cells, which remained highly susceptible to anoikis. We postulate that both anoikis-resistance and angiogenic-competence contribute to tumor formation. Development of anoikis-resistance can be then viewed as a precondition for expression of the tumorigenic phenotype. Our results suggest that even when angiogenesis is not a rate limiting factor (e.g. in vitro) the selective pressures of solid tumor-like, 3-dimensional growth conditions favoring anoikis resistance result in collateral induction of a proangiogenic phenotype." @default.
• W1982596539 created "2016-06-24" @default.
• W1982596539 creator A5002441379 @default.
• W1982596539 creator A5010799165 @default.
• W1982596539 creator A5033748917 @default.
• W1982596539 creator A5038690420 @default.
• W1982596539 creator A5041567552 @default.
• W1982596539 creator A5053250638 @default.
• W1982596539 creator A5083747970 @default.
• W1982596539 date "1999-04-01" @default.
• W1982596539 modified "2023-10-09" @default.
• W1982596539 title "Collateral Expression of Proangiogenic and Tumorigenic Properties in Intestinal Epithelial Cell Variants Selected for Resistance to Anoikis" @default.
• W1982596539 cites W1495198008 @default.
• W1982596539 cites W1607187127 @default.
• W1982596539 cites W1966121721 @default.
• W1982596539 cites W1970866978 @default.
• W1982596539 cites W197395184 @default.
• W1982596539 cites W1978344336 @default.
• W1982596539 cites W1979139036 @default.
• W1982596539 cites W1981393628 @default.
• W1982596539 cites W1985712533 @default.
• W1982596539 cites W1985804036 @default.
• W1982596539 cites W1992158081 @default.
• W1982596539 cites W1995782079 @default.
• W1982596539 cites W2001258296 @default.
• W1982596539 cites W2004346157 @default.
• W1982596539 cites W2009257395 @default.
• W1982596539 cites W2010307195 @default.
• W1982596539 cites W2013312964 @default.
• W1982596539 cites W2015344488 @default.
• W1982596539 cites W2020903752 @default.
• W1982596539 cites W2027737365 @default.
• W1982596539 cites W2028999918 @default.
• W1982596539 cites W2039074795 @default.
• W1982596539 cites W2049154530 @default.
• W1982596539 cites W2062352019 @default.
• W1982596539 cites W2069299583 @default.
• W1982596539 cites W2087347929 @default.
• W1982596539 cites W2091130756 @default.
• W1982596539 cites W2094830604 @default.
• W1982596539 cites W2097767970 @default.
• W1982596539 cites W2101073259 @default.
• W1982596539 cites W2102369096 @default.
• W1982596539 cites W2124559417 @default.
• W1982596539 cites W2124891058 @default.
• W1982596539 cites W2132601924 @default.
• W1982596539 cites W2158743409 @default.
• W1982596539 cites W2324677651 @default.
• W1982596539 doi "https://doi.org/10.1038/sj.neo.7900001" @default.
• W1982596539 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1716053" @default.
• W1982596539 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10935467" @default.
• W1982596539 hasPublicationYear "1999" @default.
• W1982596539 type Work @default.
• W1982596539 sameAs 1982596539 @default.
• W1982596539 citedByCount "39" @default.
• W1982596539 countsByYear W19825965392012 @default.
• W1982596539 countsByYear W19825965392014 @default.
• W1982596539 countsByYear W19825965392015 @default.
• W1982596539 countsByYear W19825965392017 @default.
• W1982596539 countsByYear W19825965392018 @default.
• W1982596539 crossrefType "journal-article" @default.
• W1982596539 hasAuthorship W1982596539A5002441379 @default.
• W1982596539 hasAuthorship W1982596539A5010799165 @default.
• W1982596539 hasAuthorship W1982596539A5033748917 @default.
• W1982596539 hasAuthorship W1982596539A5038690420 @default.
• W1982596539 hasAuthorship W1982596539A5041567552 @default.
• W1982596539 hasAuthorship W1982596539A5053250638 @default.
• W1982596539 hasAuthorship W1982596539A5083747970 @default.
• W1982596539 hasBestOaLocation W19825965391 @default.
• W1982596539 hasConcept C104317684 @default.
• W1982596539 hasConcept C121608353 @default.
• W1982596539 hasConcept C127561419 @default.
• W1982596539 hasConcept C127716648 @default.
• W1982596539 hasConcept C152000582 @default.
• W1982596539 hasConcept C190283241 @default.
• W1982596539 hasConcept C203014093 @default.
• W1982596539 hasConcept C2780394083 @default.
• W1982596539 hasConcept C31573885 @default.
• W1982596539 hasConcept C502942594 @default.
• W1982596539 hasConcept C54355233 @default.
• W1982596539 hasConcept C555283112 @default.
• W1982596539 hasConcept C62112901 @default.
• W1982596539 hasConcept C81885089 @default.
• W1982596539 hasConcept C86803240 @default.
• W1982596539 hasConcept C95444343 @default.
• W1982596539 hasConceptScore W1982596539C104317684 @default.
• W1982596539 hasConceptScore W1982596539C121608353 @default.
• W1982596539 hasConceptScore W1982596539C127561419 @default.
• W1982596539 hasConceptScore W1982596539C127716648 @default.
• W1982596539 hasConceptScore W1982596539C152000582 @default.
• W1982596539 hasConceptScore W1982596539C190283241 @default.
• W1982596539 hasConceptScore W1982596539C203014093 @default.
• W1982596539 hasConceptScore W1982596539C2780394083 @default.
• W1982596539 hasConceptScore W1982596539C31573885 @default.
• W1982596539 hasConceptScore W1982596539C502942594 @default.
• W1982596539 hasConceptScore W1982596539C54355233 @default.
• W1982596539 hasConceptScore W1982596539C555283112 @default.
• W1982596539 hasConceptScore W1982596539C62112901 @default.

• next