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- W1982602014 abstract "In previous study, we have shown that β1,4-galactosyltransferase V (GalT V) functions as a positive growth regulator in glioma. Here, we reported that down-regulation of the expression of GalT V in SHG44 cells by transfection with antisense cDNA specifically up-regulated the expression of cell surface integrin β1 without the change of its mRNA, and with integrin β1 125 kDa mature form increased and 105 kDa precursor form decreased. It is well known that the N-glycans of integrins modulate the location and functions of integrins. The SHG44 cells transfected with antisense cDNA of GalT V demonstrated decreased Golgi localization of integrin β1, strengthened the interaction between integrin α5 and β1 subunit, and enhanced the adhesion ability to fibronectin and the level of focal adhesion kinase phosphorylation. Our results suggested that the down-regulation of the expression of GalT V could promote the expression of cell surface integrin β1 and subsequently inhibit glioma malignant phenotype." @default.
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- W1982602014 date "2006-05-01" @default.
- W1982602014 modified "2023-10-16" @default.
- W1982602014 title "Down-regulation of the expression of β1,4-galactosyltransferase V promotes integrin β1 maturation" @default.
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- W1982602014 doi "https://doi.org/10.1016/j.bbrc.2006.03.046" @default.
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