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- W1982603939 endingPage "2043" @default.
- W1982603939 startingPage "2036" @default.
- W1982603939 abstract "Bcl-2 family proteins play central roles in the regulation of most, if not all, apoptotic pathways, and hence this family plays a critical role in oncogenesis. The Bcl-2 homology 3 (BH3)-only members of this family are proapoptotic, promoting apoptosis by sensing cellular stresses: that is, they are activated or induced in response to stress stimuli. These BH3-only proteins then interfere with the function of prosurvival Bcl-2 family members, thereby promoting the progression of apoptosis. It has long been recognized that the induction and activation of each of the BH3-only proteins are subject to the type of stress stimulus. Although it was originally assumed that all the BH3-only proteins exert similar effects on the downstream apoptotic machinery, recent studies have uncovered their distinct functional properties, indicating the operation of more intricate, versatile control mechanisms of apoptosis. In this review, we will summarize recent findings on the diversity in the activation and function of BH3-only proteins. In particular, we focus on the overlapping and individual roles of 2 BH3-only proteins, Puma and Noxa, in the context of the apoptotic response induced by the tumor suppressor p53." @default.
- W1982603939 created "2016-06-24" @default.
- W1982603939 creator A5062414007 @default.
- W1982603939 creator A5072790141 @default.
- W1982603939 date "2006-03-29" @default.
- W1982603939 modified "2023-10-13" @default.
- W1982603939 title "BH3-only proteins: Integrated control point of apoptosis" @default.
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- W1982603939 doi "https://doi.org/10.1002/ijc.21751" @default.
- W1982603939 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16572413" @default.
- W1982603939 hasPublicationYear "2006" @default.
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