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• W1982605681 endingPage "1399" @default.
• W1982605681 startingPage "1399" @default.
• W1982605681 abstract "Sirtuins are a highly conserved family of nicotinamide adenine dinucleotide (NAD(+))-dependent protein lysine modifying enzymes with deacetylase, adenosine diphosphateribosyltransferase and other deacylase activities. Mammals have seven sirtuins, namely SIRT1-7. They are key regulators for a wide variety of cellular and physiological processes such as cell proliferation, differentiation, DNA damage and stress response, genome stability, cell survival, metabolism, energy homeostasis, organ development, aging, and cancer. Here we present an extensive literature review of the roles of mammalian sirtuins, particularly SIRT1 as that is the most studied sirtuin, in human epithelial, neuronal, hematopoietic, and mesenchymal malignancies, covering breast, prostate, lung, thyroid, liver, colon, gastric, pancreatic, ovarian, and cervical cancers, tumors of the central nervous system, leukemia and lymphoma, and soft tissue sarcomas. Collective evidence suggests sirtuins are involved in both promoting and suppressing tumorigenesis depending on cellular and molecular contexts. We discuss the potential use of sirtuin modulators, especially sirtuin inhibitors, in cancer treatment." @default.
• W1982605681 created "2016-06-24" @default.
• W1982605681 creator A5039384923 @default.
• W1982605681 creator A5063042101 @default.
• W1982605681 creator A5075246689 @default.
• W1982605681 date "2013-10-01" @default.
• W1982605681 modified "2023-09-29" @default.
• W1982605681 title "The emerging and diverse roles of sirtuins in cancer: a clinical perspective" @default.
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