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• W1982606786 endingPage "91" @default.
• W1982606786 startingPage "77" @default.
• W1982606786 abstract "Multivesicular bodies (MVBs) deliver cargo destined for degradation to the vacuole or lysosome. The ESCRT (endosomal sorting complex required for transport) pathway is a key mediator of MVB biogenesis, but it also plays critical roles in retroviral budding and cytokinetic abscission. Despite these diverse roles, the ESCRT pathway can be simply seen as a cargo-recognition and membrane-sculpting machine viewable from three distinct perspectives: (1) the ESCRT proteins themselves, (2) the cargo they sort, and (3) the membrane they deform. Here, we review ESCRT function from these perspectives and discuss how ESCRTs may drive vesicle budding." @default.
• W1982606786 created "2016-06-24" @default.
• W1982606786 creator A5025638265 @default.
• W1982606786 creator A5055917006 @default.
• W1982606786 creator A5072275660 @default.
• W1982606786 date "2011-07-01" @default.
• W1982606786 modified "2023-10-14" @default.
• W1982606786 title "The ESCRT Pathway" @default.
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