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• W1982619942 startingPage "S69" @default.
• W1982619942 abstract "The translocation of particulate matter across the gastrointestinal tract is now a well documented phenomenon offering new potential for the delivery of drugs with poor dissolution profiles and labile chemistries via encapsulation in biodegradable nanoparticles. The last few years have seen an acceleration in the number of publications describing the varying facets of this approach and the multidisciplinary nature of this field. This review delineates data from this rather fragmented area and from cognate fields to provide a physicochemical viewpoint of the importance of surface chemistries of oral drug delivery vehicles and their interactions in and with gut contents prior to uptake. The role of lymphoid and non-lymphoid tissues is examined, and the role of bioadhesion is discussed. The exciting potential of molecular encapsulation of drugs via dendrimers and star branched molecules is discussed in the context of nanotechnological applications for the oral route. Evolving vistas include a better understanding of the plasticity of the intestinal epithelium and M-cell induction as well as the influence of disease states on particulate uptake. In this review we address a number of issues deemed vital to an understanding of the subject including (i) some background knowledge on particulate uptake (the subject of several reviews), (ii) factors affecting uptake such as diameter and surface charge and character, (iii) the dynamic nature of particle interactions in the gut, (iv) the dynamic nature of the processes of capture, adhesion, uptake, transcytosis and translocation, and (v) the influence of surface ligands." @default.
• W1982619942 created "2016-06-24" @default.
• W1982619942 creator A5016362603 @default.
• W1982619942 creator A5077262435 @default.
• W1982619942 date "2001-10-01" @default.
• W1982619942 modified "2023-10-09" @default.
• W1982619942 title "Transcytosis of nanoparticle and dendrimer delivery systems: evolving vistas" @default.
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• W1982619942 doi "https://doi.org/10.1016/s0169-409x(01)00184-3" @default.
• W1982619942 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11576696" @default.
• W1982619942 hasPublicationYear "2001" @default.
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