Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982619962> ?p ?o ?g. }
Showing items 1 to 53 of
53
with 100 items per page.
- W1982619962 abstract "Improving our knowledge on the rate at which the brain shrinks, metabolism declines and ß-amyloid deposition accumulates over the course of Alzheimer's disease (AD) provides essential tools to monitor the effects of new therapeutics. Moreover, the sequence of events and causal relationships between the different alterations is one of the most pressing questions in current AD research, as we need to identify the appropriate target for future therapeutic developments, i.e. the initial causal event. For these reasons, it is crucial to further our knowledge on the progression of AD-related pathological processes. The presentation will address the role of neuroimaging in identifying the main structural and functional brain alterations over the course of Alzheimer's disease, with an emphasis on their progression and chronology. The first part of the presentation will give an overview on where the pathology starts and how it progresses from longitudinal neuroimaging studies including structural and functional MRI, FDG-PET, and amyloid neuroimaging. The second part will tend to be more interpretative, first presenting the main models proposed for the sequence of alterations over the course of the disease. The different strategies used to test these models and more generally to address the question of chronology and causal relationships will then be introduced, and the few results obtained to date as first attempts to answer to this pressing question will be presented. Multimodal longitudinal neuroimaging explorations have been possible, then accessible, and are now available for analyses. There is no clear-cut response as regard to the chronology of events for now, but there are exciting avenues for the future as some pieces of the puzzle start to fit together." @default.
- W1982619962 created "2016-06-24" @default.
- W1982619962 creator A5007086576 @default.
- W1982619962 date "2011-07-01" @default.
- W1982619962 modified "2023-09-30" @default.
- W1982619962 title "PL-02-03: Seing what Alois Alzheimer Couldn't See: The Utility of Neuroimaging in Tracking the Progression of Alzheimer's Disease and the Chronology of Events" @default.
- W1982619962 doi "https://doi.org/10.1016/j.jalz.2011.05.803" @default.
- W1982619962 hasPublicationYear "2011" @default.
- W1982619962 type Work @default.
- W1982619962 sameAs 1982619962 @default.
- W1982619962 citedByCount "0" @default.
- W1982619962 crossrefType "journal-article" @default.
- W1982619962 hasAuthorship W1982619962A5007086576 @default.
- W1982619962 hasBestOaLocation W19826199621 @default.
- W1982619962 hasConcept C126838900 @default.
- W1982619962 hasConcept C142724271 @default.
- W1982619962 hasConcept C15744967 @default.
- W1982619962 hasConcept C169760540 @default.
- W1982619962 hasConcept C180747234 @default.
- W1982619962 hasConcept C188147891 @default.
- W1982619962 hasConcept C2777601897 @default.
- W1982619962 hasConcept C2779134260 @default.
- W1982619962 hasConcept C58693492 @default.
- W1982619962 hasConcept C71924100 @default.
- W1982619962 hasConceptScore W1982619962C126838900 @default.
- W1982619962 hasConceptScore W1982619962C142724271 @default.
- W1982619962 hasConceptScore W1982619962C15744967 @default.
- W1982619962 hasConceptScore W1982619962C169760540 @default.
- W1982619962 hasConceptScore W1982619962C180747234 @default.
- W1982619962 hasConceptScore W1982619962C188147891 @default.
- W1982619962 hasConceptScore W1982619962C2777601897 @default.
- W1982619962 hasConceptScore W1982619962C2779134260 @default.
- W1982619962 hasConceptScore W1982619962C58693492 @default.
- W1982619962 hasConceptScore W1982619962C71924100 @default.
- W1982619962 hasIssue "4S_Part_8" @default.
- W1982619962 hasLocation W19826199621 @default.
- W1982619962 hasOpenAccess W1982619962 @default.
- W1982619962 hasPrimaryLocation W19826199621 @default.
- W1982619962 hasRelatedWork W1908554631 @default.
- W1982619962 hasRelatedWork W2027987782 @default.
- W1982619962 hasRelatedWork W2065074698 @default.
- W1982619962 hasRelatedWork W2085642841 @default.
- W1982619962 hasRelatedWork W2087328730 @default.
- W1982619962 hasRelatedWork W2098402537 @default.
- W1982619962 hasRelatedWork W2462255595 @default.
- W1982619962 hasRelatedWork W2803278045 @default.
- W1982619962 hasRelatedWork W4231719912 @default.
- W1982619962 hasRelatedWork W4386225694 @default.
- W1982619962 hasVolume "7" @default.
- W1982619962 isParatext "false" @default.
- W1982619962 isRetracted "false" @default.
- W1982619962 magId "1982619962" @default.
- W1982619962 workType "article" @default.