FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982634375> ?p ?o ?g. }

• W1982634375 endingPage "e54032" @default.
• W1982634375 startingPage "e54032" @default.
• W1982634375 abstract "Trypanosoma brucei is a unicellular flagellated eukaryotic parasite that causes African trypanosomiasis in human and domestic animals with devastating health and economic consequences. Recent studies have revealed the important roles of the single flagellum of T. brucei in many aspects, especially that the flagellar motility is required for the viability of the bloodstream form T. brucei, suggesting that impairment of the flagellar function may provide a promising cure for African sleeping sickness. Knowing the flagellum proteome is crucial to study the molecular mechanism of the flagellar functions. Here we present a novel computational method for identifying flagellar proteins in T. brucei, called trypanosome flagellar protein predictor (TFPP). TFPP was developed based on a list of selected discriminating features derived from protein sequences, and could predict flagellar proteins with ∼92% specificity at a ∼84% sensitivity rate. Applied to the whole T. brucei proteome, TFPP reveals 811 more flagellar proteins with high confidence, suggesting that the flagellar proteome covers ∼10% of the whole proteome. Comparison of the expression profiles of the whole T. brucei proteome at three typical life cycle stages found that ∼45% of the flagellar proteins were significantly changed in expression levels between the three life cycle stages, indicating life cycle stage-specific regulation of flagellar functions in T. brucei. Overall, our study demonstrated that TFPP is highly effective in identifying flagellar proteins and could provide opportunities to study the trypanosome flagellar proteome systematically. Furthermore, the web server for TFPP can be freely accessed at http:/wukong.tongji.edu.cn/tfpp." @default.
• W1982634375 created "2016-06-24" @default.
• W1982634375 creator A5005381760 @default.
• W1982634375 creator A5018475553 @default.
• W1982634375 creator A5027449288 @default.
• W1982634375 creator A5037461695 @default.
• W1982634375 creator A5065936585 @default.
• W1982634375 creator A5073883114 @default.
• W1982634375 creator A5083581319 @default.
• W1982634375 creator A5088657051 @default.
• W1982634375 date "2013-01-17" @default.
• W1982634375 modified "2023-10-03" @default.
• W1982634375 title "TFPP: An SVM-Based Tool for Recognizing Flagellar Proteins in Trypanosoma brucei" @default.
• W1982634375 cites W1970416608 @default.
• W1982634375 cites W1971668778 @default.
• W1982634375 cites W1974483160 @default.
• W1982634375 cites W1996518652 @default.
• W1982634375 cites W2005750609 @default.
• W1982634375 cites W2014509414 @default.
• W1982634375 cites W2029163288 @default.
• W1982634375 cites W2038163496 @default.
• W1982634375 cites W2043338013 @default.
• W1982634375 cites W2043776679 @default.
• W1982634375 cites W2047817180 @default.
• W1982634375 cites W2056960490 @default.
• W1982634375 cites W2057663059 @default.
• W1982634375 cites W2063608300 @default.
• W1982634375 cites W2069725293 @default.
• W1982634375 cites W2087548537 @default.
• W1982634375 cites W2091038602 @default.
• W1982634375 cites W2094201044 @default.
• W1982634375 cites W2101070228 @default.
• W1982634375 cites W2101553897 @default.
• W1982634375 cites W2101745615 @default.
• W1982634375 cites W2109553965 @default.
• W1982634375 cites W2128441720 @default.
• W1982634375 cites W2128538135 @default.
• W1982634375 cites W2131965976 @default.
• W1982634375 cites W2134278790 @default.
• W1982634375 cites W2135567157 @default.
• W1982634375 cites W2143519602 @default.
• W1982634375 cites W2144343116 @default.
• W1982634375 cites W2146516445 @default.
• W1982634375 cites W2147130489 @default.
• W1982634375 cites W2152458080 @default.
• W1982634375 cites W2152770371 @default.
• W1982634375 cites W2154110104 @default.
• W1982634375 cites W2158173168 @default.
• W1982634375 cites W2158275075 @default.
• W1982634375 cites W2160678789 @default.
• W1982634375 cites W2160979370 @default.
• W1982634375 cites W2161682498 @default.
• W1982634375 cites W2162792752 @default.
• W1982634375 cites W2170700642 @default.
• W1982634375 doi "https://doi.org/10.1371/journal.pone.0054032" @default.
• W1982634375 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3547966" @default.
• W1982634375 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23349782" @default.
• W1982634375 hasPublicationYear "2013" @default.
• W1982634375 type Work @default.
• W1982634375 sameAs 1982634375 @default.
• W1982634375 citedByCount "1" @default.
• W1982634375 countsByYear W19826343752014 @default.
• W1982634375 crossrefType "journal-article" @default.
• W1982634375 hasAuthorship W1982634375A5005381760 @default.
• W1982634375 hasAuthorship W1982634375A5018475553 @default.
• W1982634375 hasAuthorship W1982634375A5027449288 @default.
• W1982634375 hasAuthorship W1982634375A5037461695 @default.
• W1982634375 hasAuthorship W1982634375A5065936585 @default.
• W1982634375 hasAuthorship W1982634375A5073883114 @default.
• W1982634375 hasAuthorship W1982634375A5083581319 @default.
• W1982634375 hasAuthorship W1982634375A5088657051 @default.
• W1982634375 hasBestOaLocation W19826343751 @default.
• W1982634375 hasConcept C104317684 @default.
• W1982634375 hasConcept C104397665 @default.
• W1982634375 hasConcept C115811362 @default.
• W1982634375 hasConcept C19843653 @default.
• W1982634375 hasConcept C2779502636 @default.
• W1982634375 hasConcept C46111723 @default.
• W1982634375 hasConcept C55493867 @default.
• W1982634375 hasConcept C58207958 @default.
• W1982634375 hasConcept C60644358 @default.
• W1982634375 hasConcept C70721500 @default.
• W1982634375 hasConcept C86803240 @default.
• W1982634375 hasConcept C95444343 @default.
• W1982634375 hasConceptScore W1982634375C104317684 @default.
• W1982634375 hasConceptScore W1982634375C104397665 @default.
• W1982634375 hasConceptScore W1982634375C115811362 @default.
• W1982634375 hasConceptScore W1982634375C19843653 @default.
• W1982634375 hasConceptScore W1982634375C2779502636 @default.
• W1982634375 hasConceptScore W1982634375C46111723 @default.
• W1982634375 hasConceptScore W1982634375C55493867 @default.
• W1982634375 hasConceptScore W1982634375C58207958 @default.
• W1982634375 hasConceptScore W1982634375C60644358 @default.
• W1982634375 hasConceptScore W1982634375C70721500 @default.
• W1982634375 hasConceptScore W1982634375C86803240 @default.
• W1982634375 hasConceptScore W1982634375C95444343 @default.
• W1982634375 hasIssue "1" @default.
• W1982634375 hasLocation W19826343751 @default.

• next