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- W1982638309 endingPage "210" @default.
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- W1982638309 abstract "Low density lipoprotein (LDL) particles are the major cholesterol carriers in circulation and their physiological function is to carry cholesterol to the cells. In the process of atherogenesis these particles are modified and they accumulate in the arterial wall. Although the composition and overall structure of the LDL particles is well known, the fundamental molecular interactions and their impact on the structure of LDL particles are not well understood. Here, the existing pieces of structural information on LDL particles are combined with computer models of the individual molecular components to give a detailed structural model and visualization of the particles. Strong evidence is presented in favor of interactions between LDL lipid constituents that lead to specific domain formation in the particles. A new three-layer model, which divides the LDL particle into outer surface, interfacial layer, and core, and which is capable of explaining some seemingly contradictory interpretations of molecular interactions in LDL particles, is also presented. A new molecular interaction model for the β-sheet structure and phosphatidylcholine headgroups is introduced and an overall view of the tertiary structure of apolipoprotein B-100 in the LDL particles is presented. This structural information is also utilized to understand and explain the molecular characteristics and interactions of modified, atherogenic LDL particles." @default.
- W1982638309 created "2016-06-24" @default.
- W1982638309 creator A5046164070 @default.
- W1982638309 creator A5051514103 @default.
- W1982638309 creator A5066669605 @default.
- W1982638309 creator A5078073418 @default.
- W1982638309 creator A5085875890 @default.
- W1982638309 date "2000-11-01" @default.
- W1982638309 modified "2023-10-17" @default.
- W1982638309 title "Structure of low density lipoprotein (LDL) particles: Basis for understanding molecular changes in modified LDL" @default.
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